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|Antigen||MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) Antibodies|
|Conjugate||This MKNK2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MKNK2 AntibodyTarget Details MKNK2 Application Details Handling References for anti-MKNK2 antibody (ABIN359310) Images
|Specificity||This antibody reacts to MNK2 (MKNK2).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MKNK2.|
Target Details MKNK2Product Details anti-MKNK2 Antibody Application Details Handling References for anti-MKNK2 antibody (ABIN359310) Images back to top
|Alternative Name||MKNK2 (MKNK2 Antibody Abstract)|
|Background||MKNK2 may play a role in the response to environmental stress and cytokines. This protein appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.Synonyms: GPRK7, MAP kinase-interacting serine/threonine-protein kinase 2, MNK2|
|Gene ID||2872, 9606|
Application DetailsProduct Details anti-MKNK2 Antibody Target Details MKNK2 Handling References for anti-MKNK2 antibody (ABIN359310) Images back to top
ELISA: 1/1,000. Western Blot: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MKNK2 Antibody Target Details MKNK2 Application Details References for anti-MKNK2 antibody (ABIN359310) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MKNK2 antibody (ABIN359310)Product Details anti-MKNK2 Antibody Target Details MKNK2 Application Details Handling Images back to top
Scheper, Parra, Wilson, Van Kollenburg, Vertegaal, Han, Proud: "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5692-705, 2003
Knauf, Tschopp, Gram: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, 2001
Scheper, Morrice, Kleijn, Proud: "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 743-54, 2001
Slentz-Kesler, Moore, Lombard, Zhang, Hollingsworth, Weiner: "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta." in: Genomics, Vol. 69, Issue 1, pp. 63-71, 2000
Haribabu, Snyderman: "Identification of additional members of human G-protein-coupled receptor kinase multigene family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 20, pp. 9398-402, 1993
ImagesProduct Details anti-MKNK2 Antibody Target Details MKNK2 Application Details Handling References for anti-MKNK2 antibody (ABIN359310) back to top