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The rs34349826 and rs6521 loci of the LHB gene were not related to male infertility, which can be further confirmed by larger-sample studies. The GG genotype combination is a protective factor against male infertility.
Homozygous nonsense mutation Trp28X in the LHB gene causes LH deficiency.
A 20-year-old male from a consanguineous family had pubertal delay, hypogonadism and undetectable LH. A homozygous c.118_120del (p.Lys40del) mutation was identified in the patient and his brother, who subsequently had the same phenotype.
In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3).
LHbeta G1052A and LHCGR G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases.
The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility.
This paper shows a conclusive contribution of Variant-Luteinizing hormone to the natural variance in male serum Luteinizing hormone levels
the frequency of v-betaLH in Denmark is similar to a number of European countries
LH, progesterone, and TSH can stimulate aldosterone.
Data indicate a modulatory effect of luteinizing hormone beta-subunit (LHB) gene polymorphisms on hyperandrogenemia phenotype of Polycystic Ovary Syndrome (PCOS) was observed.
No association was found between poor ovarian response to ovarian stimulation and variant-betaLH.
Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth.
Negative fetal FSH/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R expression in the tuberal hypothalamus.
FOXO1 transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells
Results suggested LH G1052A mutation might influence polycystic ovary syndrome susceptibility and phenotypes.
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
the presence of LHbeta G1502A and ERbeta G+1730A polymorphisms is associated with infertility and endometriosis associated infertility.When two polymorphisms are present it does not appear to increase the chance of developing endometriosis or infertility.
Both normal-weight and overweight women with classic PCOS phenotypes present higher LH levels and LH-to-FSH ratios than women with similar BMI but the newer phenotypes.
A dileucine determinant in the carboxyl terminal sequence of the luteinizing hormone beta subunit is implicated in the regulated secretion of lutropin
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males.
WT1 can modulate LHbeta transcription with differential roles for the two WT1 variants
progesterone signaling specifically in kisspeptin cells essential for the positive feedback induction of normal LH surges, ovulation, and normal fertility in females
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe.
This is the first conclusive evidence for the physiological importance of the activation of Gq/11 by the LH receptor and for the involvement of Galphaq/11 in ovulation.
The development of an ELISA method to assess luteinzing hormone secretion through sexual maturation in mice is reported.
GnRH stimulates AMPK, and AMPK inhibition suppresses GnRH-stimulated LHbeta transcription.
Data suggest that highly bioactive luteinizing hormone (both alpha [Cga] and beta [Lhb] subunits) is produced by embryo/blastocyst at time of implantation; Lhb transcripts are detected in blastocysts on day 6 after fertilization.
Data indicate that free fatty acids up-regulated luteinizing hormone beta (Lhb) mRNA expression acutely but suppressed follicle stimulating hormone beta (Fshb) mRNA expression.
A molecular mechanism involving Egr1 as a critical integrator of complex formation on the LHbeta promoter during GnRH induction and glucocorticoid receptor repression.
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
SN activates the protein kinase A (PKA) and cAMP-induced ERK signaling pathways in the LH-secreting mouse LbetaT2 pituitary cell line
current results show that the action of GnRH in the regulation of gonadotropin subunit expression is enhanced by the presence of PAC1Rs
LHbeta promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII).
The data indicate that the absence of estrogen in concert with elevated levels of circulating gonadotrophins, principally LH, is responsible for the abnormal reproductive phenotype of the female Aromatase knockout mouse.
The LIM-homeodomain transcription factor Isl-1 functions to increase FSHbeta/LHbeta gene transcription, and mediates the effects of leptin on gonadotropin synthesis.
Reference intervals were calculated for male testosterone, SHBG, FSH and LH in serum from 599 individuals.
An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation
Changes in the expression of genes encoding beta-LH and GnRH-R were also demonstrated across the estrous cycle in swine
This study determined the cDNA sequences of the luteinizing hormone beta-subunit (LHB) from Japanese White (JW), New Zealand White (NZW), and Dutch-Belted (Dutch) rabbits, and we compared these LHB sequences with those of other mammals.
Synthesis and characterization of biologically active recombinant elk and horse FSH.
The 104-109 region of the beta eLH/CG subunit is essential for the secretion of a fully folded beta alpha eLH/CG and for its FSH activity but not for its LH activity.
Action of Lh and Fsh signaling is redundant in that either alone can support zebrafish spermatogenesis.
LH-deficient zebrafish (lhb(-/-)) showed normal gonadal growth, but the females failed to spawn and were therefore infertile.
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
, interstitial cell stimulating hormone, beta chain
, luteinizing hormone beta subunit
, lutropin beta chain
, lutropin subunit beta
, luteinizing hormone subunit beta
, Luteinizing hormone (lutropin) subunit beta
, LH-beta subunit
, luteinizing hormone beta polypeptide
, lutropin/choriogonadotropin beta chain
, lutropin/choriogonadotropin subunit beta
, interstitial cell-stimulating hormone
, leutenising hormone beta
, LH beta
, LOW QUALITY PROTEIN: lutropin subunit beta-like
, Luteinizing hormone subunit beta
, Lutropin/choriogonadotropin beta chain
, Lutropin/choriogonadotropin subunit beta
, chorionic gonadotropin beta subunit
, luteinizing hormone beta-subunit
, luteinizing hormone/chorionic gonadotrophin beta-subunit
, Lutropin beta chain
, glycoprotein luteinizing hormone, beta subunit
, Gth II
, LH beta 2
, luteinizing hormone beta 1
, luteinizing hormone beta 2
, luteinizing hormone, beta polypeptide
, luteinizing hormone beta polypeptide L homeolog
, lutropin beta subunit