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Homozygous nonsense mutation Trp28X in the LHB gene causes LH deficiency.
LHbeta G1052A and LHCGR (show LHCGR Proteins) G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases.
The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility.
LH, progesterone, and TSH can stimulate aldosterone.
Data indicate a modulatory effect of luteinizing hormone beta-subunit (LHB) gene polymorphisms on hyperandrogenemia phenotype of Polycystic Ovary Syndrome (PCOS) was observed.
Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth.
Negative fetal FSH (show BRD2 Proteins)/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R (show KISS1R Proteins) expression in the tuberal hypothalamus.
FOXO1 (show FOXO1 Proteins) transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1 (show YAP1 Proteins); however, the preovulatory inhibition of YAP1 (show YAP1 Proteins) activity in granulosa cells is a prerequisite of LH actions.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb (show FSHB Proteins)), and intracellular adhesion molecule (show NCAM1 Proteins)-5 (Icam5 (show ICAM5 Proteins)) in females but only decreased expression of Icam5 (show ICAM5 Proteins) in males.
WT1 (show WT1 Proteins) can modulate LHbeta transcription with differential roles for the two WT1 (show WT1 Proteins) variants
SCGB3A2 (show SCGB3A2 Proteins) regulates FSH (show BRD2 Proteins)/LH production in the anterior pituitary lobe.
This is the first conclusive evidence for the physiological importance of the activation of Gq/11 by the LH receptor (show LHCGR Proteins) and for the involvement of Galphaq (show GNAQ Proteins)/11 in ovulation.
GnRH (show GNRH1 Proteins) stimulates AMPK (show PRKAA1 Proteins), and AMPK (show PRKAA1 Proteins) inhibition suppresses GnRH (show GNRH1 Proteins)-stimulated LHbeta transcription.
Data suggest that highly bioactive luteinizing hormone (both alpha [Cga (show CGA Proteins)] and beta [Lhb] subunits) is produced by embryo/blastocyst at time of implantation; Lhb transcripts are detected in blastocysts on day 6 after fertilization.
Data indicate that free fatty acids up-regulated luteinizing hormone beta (Lhb) mRNA expression acutely but suppressed follicle stimulating hormone beta (Fshb (show FSHB Proteins)) mRNA expression.
A molecular mechanism involving Egr1 (show EGR1 Proteins) as a critical integrator of complex formation on the LHbeta promoter during GnRH (show GNRH1 Proteins) induction and glucocorticoid receptor (show NR3C1 Proteins) repression.
Changes in the expression of genes encoding beta-LH and GnRH-R (show GNRHR Proteins) were also demonstrated across the estrous cycle in swine
This study determined the cDNA sequences of the luteinizing hormone beta-subunit (LHB) from Japanese White (JW), New Zealand White (NZW), and Dutch-Belted (Dutch) rabbits, and we compared these LHB sequences with those of other mammals.
Synthesis and characterization of biologically active recombinant elk (show KCNH8 Proteins) and horse FSH (show BRD2 Proteins).
The 104-109 region of the beta eLH/CG subunit is essential for the secretion of a fully folded beta alpha eLH/CG and for its FSH (show BRD2 Proteins) activity but not for its LH activity.
Action of Lh and Fsh (show BRD2 Proteins) signaling is redundant in that either alone can support zebrafish spermatogenesis.
LH-deficient zebrafish (lhb(-/-)) showed normal gonadal growth, but the females failed to spawn and were therefore infertile.
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
, interstitial cell stimulating hormone, beta chain
, luteinizing hormone beta subunit
, lutropin beta chain
, lutropin subunit beta
, luteinizing hormone subunit beta
, Luteinizing hormone (lutropin) subunit beta
, LH-beta subunit
, luteinizing hormone beta polypeptide
, lutropin/choriogonadotropin beta chain
, lutropin/choriogonadotropin subunit beta
, interstitial cell-stimulating hormone
, leutenising hormone beta
, LH beta
, LOW QUALITY PROTEIN: lutropin subunit beta-like
, Luteinizing hormone subunit beta
, Lutropin/choriogonadotropin beta chain
, Lutropin/choriogonadotropin subunit beta
, chorionic gonadotropin beta subunit
, luteinizing hormone beta-subunit
, luteinizing hormone/chorionic gonadotrophin beta-subunit
, Lutropin beta chain
, glycoprotein luteinizing hormone, beta subunit
, Gth II
, LH beta 2
, luteinizing hormone beta 1
, luteinizing hormone beta 2
, luteinizing hormone, beta polypeptide
, luteinizing hormone beta polypeptide L homeolog
, lutropin beta subunit