anti-Dog (Canine) CAMK2A antibody for BioImaging
Recommended CAMK2A Antibody (supplied by: Log in to see )
- Antigen
-
Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) Antibodies
show synonyms for this antigen- camk2
- camk2b
- zgc:112538
- zgc:123320
- CAMKA
- CaMKII
- R74975
- mKIAA0968
- PK2CDD
- PKCCD
- calcium/calmodulin dependent protein kinase II alpha
- calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog
- calcium/calmodulin-dependent protein kinase II alpha
- CAMK2A
- camk2a.S
- camk2a
- Camk2a
- Epitope
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AA 448-460
Alternatives - Reactivity
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Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Mouse
Alternatives - Clonality
- Conjugate
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This CAMK2A antibody is un-conjugated
Alternatives - Application
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BioImaging (BI), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives - Options
- Supplier
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- Supplier Product No.
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Available images
| Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ABIN968457 | BI IF IHC WB | Mouse | IgG1 | AA 448-460 | Log in to see | 45-CaM Kinase II | 5 |
General |
|
|---|---|
| Antigen | Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) Antibodies |
| Epitope | AA 448-460 Alternatives |
| Reactivity | Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives |
| Host | Mouse Alternatives |
| Clonality (Clone) | |
| Conjugate | This CAMK2A antibody is un-conjugated Alternatives |
| Application |
BioImaging (BI), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
|
|
5 references available |
| Supplier | Log in to see |
Product Details anti-CAMK2A AntibodyTarget Details CAMK2A Application Details Handling References for anti-CAMK2A antibody (ABIN968458) Images |
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| Cross-Reactivity | Mouse (Murine), Human, Dog (Canine) |
| Characteristics |
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results. 2. Please refer to us for technical protocols. 3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. 4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. |
| Purification | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. |
| Immunogen | Rat CaM Kinase IIalpha aa. 448-460 |
| Clone | 45-CaM Kinase II |
| Isotype | IgG1 |
Target Details CAMK2AProduct Details anti-CAMK2A Antibody Application Details Handling References for anti-CAMK2A antibody (ABIN968458) Images back to top |
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| Antigen | |
| Alternative Name | CaM Kinase II (CAMK2A Antibody Abstract) |
| Background |
Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, alpha and beta, at a ratio of 2:1 and homomers of alpha subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the alpha and beta subunits, which results in a substantial increase in its affinity for Ca2+/calmodulin. Synonyms: Ca2+/calmodulin-dependent protein kinase II |
| Molecular Weight | 52 kDa |
| Pathways | WNT Signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction |
Application DetailsProduct Details anti-CAMK2A Antibody Target Details CAMK2A Handling References for anti-CAMK2A antibody (ABIN968458) Images back to top |
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| Comment |
Related Products: ABIN967389, ABIN968545 |
| Restrictions | For Research Use only |
HandlingProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details References for anti-CAMK2A antibody (ABIN968458) Images back to top |
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| Format | Liquid |
| Concentration | 250 μg/mL |
| Buffer | Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide. |
| Preservative | Sodium azide |
| Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Storage | -20 °C |
| Storage Comment | Store undiluted at -20°C. |
References for anti-CAMK2A antibody (ABIN968458)Product Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Handling Images back to top |
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| Product cited in: |
Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 Zong, Ren, Young, Pypaert, Mu, Birnbaum, Shulman: "AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 25, pp. 15983-7, 2002 Brocke, Chiang, Wagner, Schulman: "Functional implications of the subunit composition of neuronal CaM kinase II." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22713-22, 1999 Ishida, Fujisawa: "Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain." in: The Journal of biological chemistry, Vol. 270, Issue 5, pp. 2163-70, 1995 Hanson, Schulman: "Neuronal Ca2+/calmodulin-dependent protein kinases." in: Annual review of biochemistry, Vol. 61, pp. 559-601, 1992 |
ImagesProduct Details anti-CAMK2A Antibody Target Details CAMK2A Application Details Handling References for anti-CAMK2A antibody (ABIN968458) back to top |
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| Supplier Images |
Western blot analysis of CaM Kinase II on a rat cerebrum lysate (First Panel). Lane 1...
Immunohistochemical staining of CaM Kinase II on rat brain (center panel). Formalin-f...
Immunofluorescence staining of SK-N-SH cells (Human neuroblastoma, ATCC HTB-11) (Seco...
anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (AA 448-460) antibody (Image 4)
anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (AA 448-460) antibody (Image 5)
anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (AA 448-460) antibody (Image 6)
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