anti-Mouse (Murine) CD40 antibody for Blocking Reagent
Recommended CD40 Antibody (supplied by: Log in to see )
- Antigen
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CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies
show synonyms for this antigen- Bp50
- CDW40
- TNFRSF5
- p50
- AI326936
- GP39
- HIGM1
- IGM
- IMD3
- T-BAM
- TRAP
- Tnfrsf5
- TNFSF5
- CD40 molecule
- CD40 antigen
- CD40
- Cd40
- Reactivity
-
Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Armenian Hamster
Alternatives - Clonality
- Conjugate
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This CD40 antibody is un-conjugated
Alternatives - Application
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Blocking Reagent (BR), Flow Cytometry (FACS)
Alternatives - Options
- Supplier
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- Supplier Product No.
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| Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ABIN2658979 | BR FACS IP IHC | PE-Cy5 | Rat | IgG2a kappa | Log in to see | 3-23 | 3 | ||
| 1 | ABIN2658980 | BR FACS IP IHC | PE-Cy5 | Rat | IgG2a kappa | Log in to see | 3-23 | 3 |
General |
|
|---|---|
| Antigen | CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies |
| Reactivity | Mouse (Murine), Rat (Rattus) Alternatives |
| Host | Armenian Hamster Alternatives |
| Clonality (Clone) | |
| Conjugate | This CD40 antibody is un-conjugated Alternatives |
| Application |
Blocking Reagent (BR), Flow Cytometry (FACS)
Alternatives
|
|
15 references available |
| Supplier | Log in to see |
Product Details anti-CD40 AntibodyTarget Details CD40 Application Details Handling References for anti-CD40 antibody (ABIN1176841) Images |
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| Brand | BD Pharmingen™ |
| Purification | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. |
| Sterility | 0.2 μm filtered |
| Endotoxin Level | Endotoxin level is ≤ 0.01 ng/μg of protein. |
| Immunogen | (BALB/c x NZB)F1 mouse-derived lymphoma WEHI-231 |
| Clone | HM40-3 |
| Isotype | IgM, kappa |
Target Details CD40Product Details anti-CD40 Antibody Application Details Handling References for anti-CD40 antibody (ABIN1176841) Images back to top |
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| Antigen | |
| Alternative Name | CD40 (CD40 Antibody Abstract) |
| Background | The HM40-3 antibody reacts with CD40, a 40-50-kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. The CD40 molecule has a central role in B-cell growth and differentiation. Furthermore, interactions of CD40 with its ligand, CD154, are involved in the initiation and effector stages of cell-mediated immune responses. CD40 may be involved in the triggering of NK cells and NK-T cells. Soluble HM40-3 antibody stimulates splenic and peritoneal B cells to proliferate in vitro. This antibody also induces spleen B cells to express the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). HM40-3 mAb has been demonstrated to inhibit the binding of soluble CD154 (gp39, CD40 Ligand) to soluble CD40 and to cell-surface CD40. This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with similar populations of Lewis, Sprague-Dawley, and LOU16 rat leukocytes. |
| Pathways | NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response |
Application DetailsProduct Details anti-CD40 Antibody Target Details CD40 Handling References for anti-CD40 antibody (ABIN1176841) Images back to top |
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| Application Notes | For immunohistochemical staining of mouse tissue, we recommend the use of purified anti-mouse CD40 mAb 3/23 in our special formulation for immunohistochemistry, Cat. No. 550285. 553721 Note: This product may appear to contain aggregation and/or precipitation of the IgM antibody. Investigators are advised to briefly spin down any particulate matter. |
| Restrictions | For Research Use only |
HandlingProduct Details anti-CD40 Antibody Target Details CD40 Application Details References for anti-CD40 antibody (ABIN1176841) Images back to top |
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| Format | Liquid |
| Concentration | 1.0 mg/mL |
| Buffer | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm filtered. |
| Preservative | Azide free |
| Storage | 4 °C |
| Storage Comment | This preparation contains no preservatives, thus it should be handled under aseptic conditions. Store undiluted at 4°C. |
References for anti-CD40 antibody (ABIN1176841)Product Details anti-CD40 Antibody Target Details CD40 Application Details Handling Images back to top |
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| Product cited in: |
Turner, Rakhmilevich, Burdelya, Neal, Imboden, Sondel, Yu: "Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 89-94, 2001 Trinité, Voisine, Yagita, Josien: "A subset of cytolytic dendritic cells in rat." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 8, pp. 4202-8, 2000 Leifeld, Trautwein, Dumoulin, Manns, Sauerbruch, Spengler: "Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure." in: The American journal of pathology, Vol. 154, Issue 6, pp. 1711-20, 1999 Akiba, Oshima, Takeda, Atsuta, Nakano, Nakajima, Nohara, Yagita, Okumura: "CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7058-66, 1999 Tomura, Yu, Ahn, Yamashita, Yang, Ono, Hamaoka, Kawano, Taniguchi, Koezuka, Fujiwara: "A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 1, pp. 93-101, 1999 Grewal, Flavell: "CD40 and CD154 in cell-mediated immunity." in: Annual review of immunology, Vol. 16, pp. 111-35, 1998 Ridge, Di Rosa, Matzinger: "A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell." in: Nature, Vol. 393, Issue 6684, pp. 474-8, 1998 Kaneko, Hirose, Abe, Yagita, Okumura, Shirai: "CD40-mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus." in: European journal of immunology, Vol. 26, Issue 12, pp. 3061-5, 1997 Kawano, Cui, Koezuka, Toura, Kaneko, Motoki, Ueno, Nakagawa, Sato, Kondo, Koseki, Taniguchi: "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1626-9, 1997 Kashiwada, Kaneko, Yagita, Okumura, Takemori: "Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells." in: European journal of immunology, Vol. 26, Issue 7, pp. 1451-8, 1996 Inaba, Inaba, Fukuba, Mori, Haruna, Doi, Adachi, Iwai, Hosaka, Hisha: "Activation of thymic B cells by signals of CD40 molecules plus interleukin-10." in: European journal of immunology, Vol. 25, Issue 5, pp. 1244-8, 1995 Foy, Laman, Ledbetter, Aruffo, Claassen, Noelle: "gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 157-63, 1994 Inaba, Witmer-Pack, Inaba, Hathcock, Sakuta, Azuma, Yagita, Okumura, Linsley, Ikehara, Muramatsu, Hodes, Steinman: "The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro." in: The Journal of experimental medicine, Vol. 180, Issue 5, pp. 1849-60, 1994 Parry, Hasbold, Holman, Klaus: "Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 6, pp. 2821-9, 1994 Noelle, Ledbetter, Aruffo: "CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation." in: Immunology today, Vol. 13, Issue 11, pp. 431-3, 1993 |
