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|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Chimpanzee, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling Images
|Specificity||This antibody recognizes MYD88 (Internal).|
Species reactivity (expected):Mouse, Rat and Canine (Dog).
Species reactivity (tested):Human.
|Purification||Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.|
|Immunogen||Peptide with sequence from the internal region of the protein sequence according to NP_002459.1. Genename: MYD88|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling Images back to top
|Alternative Name||MYD88 (MYD88 Antibody Abstract)|
|Background||Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL1R and is involved in the inflammatory response induced by IL1, IL18 and LPS. MyD88 associates with and recruits IRAK to IL1 receptor complex in response to IL1. This pathway further leads to activation of NFkB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL1 and IL18, and MyD88 deficient mice lack responses to bacterial product LPS that employs Toll like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 has a wide tissue distribution.Synonyms: Myeloid differentiation primary response protein MyD88|
|Gene ID||4615, 9606|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling Images back to top
Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.03-0.1 μg/mL. Approx 33 kDa band observed in HumanThymus lysates(calculated MW of 33.3 kDa according to NP_002459.1). Immunohistochemistry: 2-5 μg/mL. In paraffin embedded tonsil, stains clusters of cells some of which are likely to be plasmacells. In the interfollicular area occasional strongly stained areas. Epithelium is weaklypositive.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Images back to top
|Buffer||Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|