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|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Epitope||AA 240-290 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling References for anti-MYD88 antibody (ABIN736881) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from mouse MyD88|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling References for anti-MYD88 antibody (ABIN736881) Images back to top
|Alternative Name||Myd88 (MYD88 Antibody Abstract)|
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Subcellular location: Cytoplasm
Synonyms: Myeloid differentiation primary response protein MyD88, Myd88
|Research Area||Immunology, Innate Immunity, Atherosclerosis|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling References for anti-MYD88 antibody (ABIN736881) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details References for anti-MYD88 antibody (ABIN736881) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-MYD88 antibody (ABIN736881)Product Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling Images back to top
|Product cited in:||
Fu, Xia, Liu, Wang, Wang, Shi, Song, Song, Song et al.: "The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin ..." in: Toxicology, Vol. 381, pp. 39-50, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Fu, Shi, Song, Liu, Wang, Wang, Song, Song: "From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 153, Issue 2, pp. 303-15, 2016
Chen, Ye, Zhang, Tang, Li, Lu, Wu, Yu, Kou: "Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils." in: International journal of molecular sciences, Vol. 17, Issue 12, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Wang, Shi, Lv, Xu, Li, Ge, Xiao, Geng, Liu: "Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-?B Activation in Microglial Cells." in: Inflammation, 2015
Lu, Liu, Gu, Ge, Wu, Ze-Ji, Qiu, Zhang, Chao, Yu: "Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 976364, 2014
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