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anti-Rat (Rattus) RIPK1 Antibodies:
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Chicken Monoclonal RIPK1 Primary Antibody for IF, IP - ABIN967985
Takahashi, Tanaka, Brannan, Jenkins, Copeland, Suda, Nagata: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. in Cell 1994
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Chicken Monoclonal RIPK1 Primary Antibody for IF, IP - ABIN967984
Devin, Lin, Yamaoka, Li, Karin, Liu Zg: The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. in Molecular and cellular biology 2001
Show all 5 Pubmed References
Human Polyclonal RIPK1 Primary Antibody for ELISA, ICC - ABIN4350584
Nilsson, Loganathan, Sekiguchi, Matsuba, Hui, Tsubuki, Tanaka, Iwata, Saito, Saido: Aβ secretion and plaque formation depend on autophagy. in Cell reports 2013
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Human Polyclonal RIPK1 Primary Antibody for IF (p), IHC (p) - ABIN715016
Luo, Roy, Xiao, Sun, Liang, Chen, Fu, Sun, Zhu, Ye, Liu: Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77. in Tumour biology 2014
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Human Monoclonal RIPK1 Primary Antibody for IP, WB - ABIN967307
Stanger, Leder, Lee, Kim, Seed: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. in Cell 1995
Human Polyclonal RIPK1 Primary Antibody for IF (p) - ABIN715023
Seifert, Werba, Tiwari, Giao Ly, Alothman, Alqunaibit, Avanzi, Barilla, Daley, Greco, Torres-Hernandez, Pergamo, Ochi, Zambirinis, Pansari, Rendon, Tippens, Hundeyin, Mani, Hajdu, Engle, Miller: The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. in Nature 2016
Human Polyclonal RIPK1 Primary Antibody for IHC, IHC (p) - ABIN4350581
Ratovitski: Phospho-ΔNp63α-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure. in FEBS letters 2015
Human Polyclonal RIPK1 Primary Antibody for ICC, IF - ABIN4350585
Hirsch, von der Wall, Hummel, Dürkop: RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells. in Laboratory investigation; a journal of technical methods and pathology 2013
Existence of a kinase-independent role of nuclear RIPK1 in the regulation of PARP1 (show PARP1 Antibodies).
Study identify and quantify over 8,000 phosphorylated peptides, among which are numerous known sites in the TNF (show TNF Antibodies)-RSC, NFkappaB (show NFKB1 Antibodies), and MAP kinase (show MAPK1 Antibodies) signaling systems. Functional analysis of S320 phosphorylation in RIPK1 demonstrates a role for this event in suppressing its kinase activity, association with CASPASE-8 (show CASP8 Antibodies) and FADD (show FADD Antibodies) proteins, and subsequent necrotic cell death during inflammatory TNFalpha (show TNF Antibodies) stimulation.
New potent RIPK1 inhibitors are reported (GSK2606414 and GSK2656157).
In conclusion, for the first time, we report that TRADD (show TRADD Antibodies), TRAF2 (show TRAF2 Antibodies), RIP1 (show UQCRFS1 Antibodies) and TAK1 (show MAP3K7 Antibodies) play a role in the regulating TNF-alpha (show TNF Antibodies) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (show TNF Antibodies) in the processes of human labour and delivery.
the in vivo effects were diametrically reversed with RIP3 (show RIPK3 Antibodies) deletion or RIP1 (show UQCRFS1 Antibodies) blockade, resulting in marked tumor protection. The dichotomy between the in vivo and in vitro results suggests that the microenvironmental milieu resulting from RIP1 (show UQCRFS1 Antibodies)/RIP3 (show RIPK3 Antibodies) signaling is likely responsible for its protumorigenic effects
Shikonin induces glioma cell necroptosis in vitro by reactive oxygen species overproduction and promoting RIP1 (show UQCRFS1 Antibodies)/RIP3 (show RIPK3 Antibodies) necrosome formation.
the cytoplasmic retinoic acid receptor gamma (show RARG Antibodies) (RARgamma) controls receptor-interacting protein kinase (show CDK7 Antibodies) 1 (RIP1 (show UQCRFS1 Antibodies))-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
SIRT2 (show SIRT2 Antibodies) and RIPK1 were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 (show SIRT2 Antibodies) protein expression in both preeclampsia and fetal growth restricted placentas was identified. RIPK1 mRNA expression was significantly increased in preeclampsia placentas. Immunofluorescence identified both SIRT2 (show SIRT2 Antibodies) and RIPK1 in the cytotrophoblast cytoplasm.
RIPK1 inhibits the transcriptional activity of VDR.
Results show that downregulation of RIP1 (show UQCRFS1 Antibodies) results in increased resistance to SN38, implying a requirement for RIP1 (show UQCRFS1 Antibodies) in mediating cytotoxicity through the TNF (show TNF Antibodies)/TNFR (show TNFRSF1A Antibodies) signaling pathway.
Pull down experiments with biotinylated Sorafenib show that it binds independently RIPK1, RIPK3 (show RIPK3 Antibodies) and MLKL. Moreover, it inhibits RIPK1 and RIPK3 (show RIPK3 Antibodies) kinase activity. In vivo Sorafenib protects against TNF (show TNF Antibodies)-induced systemic inflammatory response syndrome (SIRS) and renal ischemia-reperfusion injury (IRI).
The study provides genetic evidence that different RIP1 kinase inactive mutations have distinct impacts on the embryogenesis of Fadd-deficient mice.
Excessive death of hepatocytes is a characteristic of liver injury. A new programmed cell death pathway has been described involving upstream death ligands such as TNF (show TNF Antibodies) and downstream kinases such as RIPK1.
TNFalpha (show TNF Antibodies)-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 (show NR2C2 Antibodies) plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis.
K45 mediated kinase activity of RIPK1 is not only important for necroptosis but it also has a key role in promoting cytokine signaling and host response to inflammatory stimuli.
Data show that the kinase activity of receptor-interacting protein kinase (show CDK7 Antibodies) 1 (RIPK1) is required for Yersinia-induced apoptosis.
p38MAPK (show MAPK14 Antibodies)/MK2 (show KCNA2 Antibodies) phosphorylation of RIPK1 is a crucial checkpoint for cell fate in inflammation and infection that determines the outcome of bacteria-host cell interaction.
MK2 (show KCNA2 Antibodies)-mediated RIPK1 phosphorylation is an important molecular mechanism limiting the sensitivity of the cells to the cytotoxic effects of TNF (show TNF Antibodies).
An alternative function for RIPK1/RIPK3 (show RIPK3 Antibodies) in vascular permeability.
these results revealed a novel, kinase-independent function of RIP1, which is essential for not only promoting TCR-induced proliferative responses but also in blocking apoptosis in mature T cells.
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
receptor (TNFRSF)-interacting serine-threonine kinase 1
, 1,3,4,5,6-pentakisphosphate 2-kinase
, inositol polyphosphate kinase 1
, inositol-1,3,4,5,6-pentakisphosphate 2-kinase
, inositol-pentakisphosphate 2-kinase
, ins(1,3,4,5,6)P5 2-kinase
, insP5 2-kinase
, cell death protein RIP
, receptor interacting protein
, receptor-interacting protein 1
, receptor-interacting serine/threonine-protein kinase 1
, serine/threonine-protein kinase RIP
, RPA interacting protein delta 2
, RPA interacting protein epsilon
, RPA-interacting protein