RIPK1 antibody (Middle Region)

Catalog No. ABIN2792131

The Rabbit Polyclonal anti-RIPK1 antibody is suitable to detect RIPK1 in samples from Human, Dog, Cow and Horse. It has been validated for WB.

Quick Overview for RIPK1 antibody (Middle Region) (ABIN2792131)

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Reactivity: Human, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RIPK1 Antibody

Binding Specificity: Middle Region

Sequence: RRRRVSHDPF AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ

Predicted Reactivity: Cow: 100%, Dog: 91%, Horse: 83%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against RIPK1. It was validated on Western Blot using a cell lysate as a positive control.

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 671 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RIPK1

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Alternative Name: RIPK1

Background: FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex.
Alias Symbols: RIP, RIP1
Protein Interaction Partner: RFFL, RIPK1, UBC, TRAF2, TRAF1, TNFRSF1A, TNF, OTUD1, YOD1, TRADD, IKBKG, FADD, CASP8, MAP3K7, BMH1, BIRC3, BIRC2, MAP3K8, OPTN, NUMBL, CFLAR, HSP90AA1, RIPK3, USP4, TNFAIP3, TNFSF10, LRRK2, TNFRSF10B, MAP3K3, HHV8GK18_gp80, DAB2IP, TNFRSF1B, IKBKB, CHUK,
Protein Size: 671

Molecular Weight: 76 kDa

Gene ID: 8737

NCBI Accession: NM_003804, NP_003795

UniProt: Q13546

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway