RIPK1 antibody (Middle Region)

Catalog No. ABIN2792131

The Rabbit Polyclonal anti-RIPK1 antibody is suitable to detect RIPK1 in samples from Human, Dog, Cow and Horse. It has been validated for WB.

Quick Overview for RIPK1 antibody (Middle Region) (ABIN2792131)

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Reactivity: Human, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RIPK1 Antibody

Binding Specificity: Middle Region

Purpose: RIPK1 Antibody - middle region

Sequence: RRRRVSHDPF AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ

Predicted Reactivity: Cow: 100%, Dog: 91%, Horse: 83%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against RIPK1. It was validated on Western Blot using a cell lysate as a positive control.

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RIPK1

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Alternative Name: RIPK1

Background:

Background Information: FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex.

Gene Name: Receptor (TNFRSF)-interacting serine-threonine kinase 1

Alternative Symbols: RIP, RIP1, AIEFL, IMD57, RIP-1

Protein Name: Receptor-interacting serine/threonine-protein kinase 1

Molecular Weight: 76kDa

Gene ID: 8737

NCBI Accession: NP_003795

UniProt: Q13546

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway