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anti-Human Androgen Receptor Antibodies:
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Human Monoclonal Androgen Receptor Primary Antibody for IHC (p), IHC - ABIN252555
Lin, Hu, Yang, Altuwaijri, Chen, Kang, Chang: Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. in The Journal of biological chemistry 2003
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Human Monoclonal Androgen Receptor Primary Antibody for IHC, ELISA - ABIN1724724
Tillman, Yuan, Gu, Fazli, Ghosh, Flynt, Gleave, Rennie, Kasper: DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. in Cancer research 2007
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Human Polyclonal Androgen Receptor Primary Antibody for IHC (p), ELISA - ABIN542902
Nishida, Yasuda: PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. in The Journal of biological chemistry 2002
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Human Monoclonal Androgen Receptor Primary Antibody for ELISA, WB - ABIN968966
Lindström, Wiklund, Adami, Bälter, Adolfsson, Grönberg: Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development. in Cancer research 2006
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Human Monoclonal Androgen Receptor Primary Antibody for ELISA, WB - ABIN965588
Zong, Chi, Wang, Yang, Zhang, Chen, Jiang, Li, Hong, Wang, Yun, Gu: Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor. in Molecular and cellular biology 2007
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Human Monoclonal Androgen Receptor Primary Antibody for IHC (f), IHC (fro) - ABIN2688843
Fuller: The steroid receptor superfamily: mechanisms of diversity. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992
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Human Polyclonal Androgen Receptor Primary Antibody for IF (p), IHC (p) - ABIN725240
Madka, Mohammed, Li, Zhang, Biddick, Patlolla, Lightfoot, Towner, Wu, Steele, Kopelovich, Rao: Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. in Cancer prevention research (Philadelphia, Pa.) 2016
Polyclonal Androgen Receptor Primary Antibody for DB, IHC (fro) - ABIN540963
Ikeda, Aihara, Sato, Akaike, Yoshizumi, Suzaki, Izawa, Fujimura, Hashizume, Kato, Yagi, Tamaki, Kawano, Matsumoto, Azuma, Kato, Matsumoto: Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis. in The Journal of biological chemistry 2005
Papillary thyroid carcinoma was characterized by high expression of ESR2 and AR, which was associated with expression and content of nuclear factors Brn-3A and TRIM16.
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.
In prostate cancer, KDM8's interaction with AR leads to the elevated expression of androgen response genes in androgen-deprived conditions.
DBC1 as a critical AR-V7 coactivator that plays a key role in the regulation of DNA binding and stability of AR-V7 and has an important physiological role in castration-resistance prostate cancer progression.
androgen receptor splice variant 7 (AR-V7) positive circulating tumor cells were important for assessing the response to abiraterone or enzalutamide therapy and for predicting disease outcome in patients with bone metastatic castration resistant-prostate cancer.
Study results demonstrated that the medians of AR gene CAG and GGN repeats length in infertile group were significantly higher than fertile men. AR expression results showed a significant increase in Sertoli cell-only syndrome group compared to control. Long stretches of tandem repeats of AR gene may negatively affect the function of the gene and consequently lead to male infertility.
Contrary to previous reports of motor- and sensory-dominant phenotypes of spinal and bulbar muscular atrophy correlating with AR CAG repeat sizes, the CAG repeat size was negatively correlated only with compound muscle action potential amplitude, and not with sensory nerve action potential amplitude.
AR target genes identified in primary fibroblasts may contribute to clinically significant and biologically important AR-regulated changes in prostate tissue.
In our study, we demonstrated that within ER+ breast cancers (BCs), the AR/ER ratio may represent an additional independent prognostic marker. Specifically, we showed that BCs with an AR/ER ratio >/=2 had a worse disease free interval and disease-specific survival.
data show that INPP4B modulates AR activity in normal prostate and its loss contributes to the AR-dependent transcriptional profile in prostate cancer.
Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.
Data suggest that HSD3B1 is unexpectedly positively regulated by androgens and AR in prostate cancer.
According to the results obtained the rs1544410 AA genotype (VDR gene) and the presence of less than 20 CAG repeats in the 1st exon (AR gene) are the risk factors for the development of prostate cancer. The het- erozygous genotype 722 CT (XRCC3 gene) demonstrated the protective effect.
androgen insensitivity syndrome caused by c.1769-1G>C mutation and activation of a cryptic splice acceptor site in the androgen receptor gene
AR mutation is associated with Klinefelter Syndrome.
AhR is higher expressed in short androgen receptor (AR) poly-glutamine polymorphism (AR-Q) tumour compared to that in long AR-Q patient.
These findings demonstrate a novel working model in which EZH2 mediates AR-induced Wnt/beta-catenin signaling activation through epigenetic modification.
Our findings also suggest that prostate cancer cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of prostate cancer patients.
AR is an independent predictor of good prognosis in Breast Cancer , particularly in grade 3 and Luminal A tumours. Discordant AR-expression between primary tumour and lymph node metastases was observed in 21.4% of cases and most often there was a switch from AR(-) primary tumour to AR(+) axillary lymph node metastases .
AR expression heterogeneity is linked to distinct castration/enzalutamide responses in castration-resistant prostate cancer.
In summary, current evidence indicates that disease progression depends on androgens, but early pathogenic events may be triggered by the mutant AR allele independent of androgens.
sex hormone receptors, estrogen receptor alpha (ERalpha) and androgen receptor (AR), mediate sexually dimorphic gene expression in mouse livers.
a novel interplay between AR and PBK that results in increased AR and ARVs expression that executes AR-mediated growth and progression of aggressive prostate cancer (PrCa), with implications for the development of PBK inhibitors for the treatment of aggressive PrCa.
Here, the authors show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in the prostate glands of ERG transgenic mice.
CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis.
Results provide evidence that androgen receptor is expressed from prenatal stages in mouse heart, supporting the proposition that androgens could be involved in mammalian heart development.
Androgens act via non-neural AR to mediate olfactory preference and neural responses to olfactory stimuli, and further, AR in non-neural tissues can promote androphilic odor preferences in male mice.
The role of ERbeta in opposing AR signaling, proliferation, and inflammation suggests that ERbeta-selective agonists may be used to prevent progression of prostate cancer, prevent fibrosis and development of benign prostatic hyperplasia, and treat prostatitis.
androgen receptor has a central role in the spontaneous regeneration of myelin
Data (including data from studies using transgenic/knockout mice) suggest that AR in insulin-secreting cells is involved in insulin secretion and inflammation; AR-deficient insulin-secreting cells exhibit altered expression of genes involved in inflammation and insulin secretion demonstrating importance of androgen action in functions of insulin-secreting cells.
Cyclic mechanical stretch modulated the proliferation of C2C12 cells, which may be attributed to the alterations of AR via IGF-1-PI3K/Akt and IGF-1-MAPK (p38, ERK1/2) pathways in C2C12 cells.
We show AR expressed in cancer-associated fibroblasts (CAFs) contributes to the tumor-promoting abilities that CAFs exert on epithelial prostate cancer cells. Further, we found that decreased AR expression in CAFs is also associated with an increase in stem cell marker gene expression in prostate cancer epithelial cells.
in clear cell renal cell carcinoma, enhances lung and liver metastases, while suppressing lymphatic metastasis
The results indicate that AR expression may be the gatekeeper of postoperative hepatocellular carcinoma recurrence
Glandular epithelial AR inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor expression in the uterus.
CDK2 phosphorylates polyQ-AR specifically at Ser(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
experimental manipulation of the prenatal androgen level, by blocking the androgen receptor with flutamide or activating the androgen receptor with dihydrotestosterone (DHT), leads to changes in the length of the fingers of all paws in males and females.
Silencing of androgen receptor rescues the muscular spinal atrophy transgenic mice.
Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
substantial up-regulation of androgen receptor expression during trophoblast giant cell differentiation suggests that androgens may be related to this process and are active products of bovine placental steroidogenesis
no association between the AR CAG polymorphism and the relative risk of prostate cancer in white Brazilian individuals with a CAG repeat
FSHR is specifically regulated through androgen receptor in granulosa cells
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 expression
Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia).
AR is a potential candidate gene for traits related to pig reproduction and performance
presence of AR during gestation in non-gonadal tissues suggests a role of androgen in these tissues
Pig ejaculated spermatozoa express androgen receptor.
Androgen receptor (AR) and Wilms' tumor gene 1 expression dramatically decreased after heat treatment in Sertoli cells
Using glucose as a disease-relevant readout, we screened 2233 molecules and identified three that consistently reduced glucose levels in insulin mutants. Most significantly, we uncovered an insulin-independent beneficial role for androgen receptor antagonism in hyperglycemia, mostly by reducing fasting glucose levels.
Zebrafish males lacking the androgen receptor courted females significantly less, showing reduced levels of stereotypic behaviors. Consistent with previous studies, disrupting androgen mechanisms can lead to behavioral changes with potential fitness consequences.
AR regulates sexual determination, testis development, and oocyte maturation and AR regulates sexually dimorphic gene expression. The ar mutant developed will be useful for modeling human endocrine function in zebrafish.
Findings suggest that zebrafish embryos attempt to compensate for the presence of an anti-androgen by increasing the number of androgen receptors available.
The isolation and characterization of zebrafish Ar were reported.
ar was expressed in discrete regions of the telencephalon, in the preoptic area, and throughout the periventricular hypothalamus, regions previously implicated in the regulation of sexually dimorphic behaviors in mammals
Sertoli cell maturation during puberty in the stallion was accompanied by a reduced expression of anti-Mullerian hormone and its receptor, arrest of cell proliferation, increased expression of androgen receptor
The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
androgen nuclear receptor variant 2
, dihydrotestosterone receptor
, nuclear receptor subfamily 3 group C member 4
, testicular feminization
, androgen receptor (Testicular feminization), same as Tfm
, androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
, androgen receptor AR
, Ar beta
, androgen receptor
, prostate androgen receptor