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ASK1 (show MAP3K5 Proteins) phosphorylated and stabilized TLX (show CD46 Proteins), which led induction of HIF-1alpha (show HIF1A Proteins), and its downstream VEGF-A (show VEGFA Proteins) in an Akt (show AKT1 Proteins) dependent manner.
The interaction between TLX (show CD46 Proteins) and TGF-beta (show TGFB1 Proteins) may play an important role in the regulation of proliferation and tumor-initiating properties of glioblastoma cells.
TLX (show CD46 Proteins) and miR-219 have an important role in both normal neurodevelopment and in s (show MLXIP Proteins)chizophrenia patient (show MLXIP Proteins) iPSC-derived NSCs. TLX has a role in regulating microRNA (show CD46 Proteins) processing, independent of its well-characterized role in transcriptional regulation.
TLX downregulation induces TET3 expression and inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells.
TLX (show CD46 Proteins) has a role in regulating growth and invasion in ERalpha (show ESR1 Proteins)-negative breast cancer cells
TLX (show CD46 Proteins) biological role in mental illness and gliomagenesis
Increased NR2E1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients.
These results suggest that let-7b, by forming a negative feedback loop with TLX (show CD46 Proteins), provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro
NR2E1 regulates CBX7 (show CBX7 Proteins) and restrains senescence in neural stem cells.
TLX (show CD46 Proteins) functions as a potent suppressor of oncogene (show RAB1A Proteins)-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1 (show CDKN1A Proteins)) ) and SIRT1 (show SIRT1 Proteins) genes
This study demonstrated that deletion of Tlx impairs motor, cognitive and anxiety-related behaviours during adolescence and adulthood in male and female mice with most effects occurring during adolescence rather than adulthood, independent of housing conditions.
This study demonstrated that Nr2e1 could be regulated by retinoic acid, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality.
Nr2e1 deficiency augments palmitate-induced oxidative stress. Nr2e1 deficiency also resulted in decreases in antioxidant enzymes and expression level of Nrf2 (show NFE2L2 Proteins).
TLX is essential for SOX2 (show SOX2 Proteins)-mediated in vivo reprogramming of astrocytes and itself is also sufficient to induce neurogenesis in the adult striatum.
TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR (show MLXIP Proteins)-219 processing. miR (show MLXIP Proteins)-219 suppresses mouse NSC proliferation downstream of TLX.
At high glucose concentrations in vitro, AdipoR1 (show ADIPOR1 Proteins) regulated the survival of neural stem cells through the p53 (show TP53 Proteins)/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX.
role in regulating STAT1 (show STAT1 Proteins) signaling and host defense
Nr2e1 regulates processes involved in neurite development and terminal retinal cell differentiation.
we have provided new candidate interacting partners and numerous well-developed testable hypotheses for understanding the pathways by which Nr2e1 functions to regulate neocortex development.
TLX overexpression promotes beta cell proliferation and decreases cell apoptosis causes significant expression changes of 225 genes.
The developmental expression profile of zebrafish nr2e1 and nr2e3 (show NR2E3 Proteins) is consistent with evolutionary conserved functions in eye and rostral brain structures.
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development.
nuclear receptor subfamily 2 group E member 1
, nuclear receptor subfamily 2, group E, member 1
, nuclear receptor TLX
, protein tailless homolog
, tailes-related receptor
, tailless homolog
, Drosophila terminal/gap gene tailless homolog