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Guinea Pig Monoclonal NR3C1 Primary Antibody for BP, ChIP - ABIN268501
Lambert, Nordeen: CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. in Molecular endocrinology (Baltimore, Md.) 2003
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Human Polyclonal NR3C1 Primary Antibody for FACS, IF (p) - ABIN726875
Takigawa, Miyazaki, Kinoshita, Kawarabayashi, Nishiyama, Hatsuse, Ono, Saitoh, Seki, Yamamoto: Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice. in American journal of physiology. Gastrointestinal and liver physiology 2013
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Human Monoclonal NR3C1 Primary Antibody for ChIP, FACS - ABIN532020
Siriani, Mitsiou, Alexis: Overexpressed glucocorticoid receptor negatively regulates gene expression under conditions that favour accumulation of non-hormone-binding forms of the receptor. in The Journal of steroid biochemistry and molecular biology 2003
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Mouse (Murine) Polyclonal NR3C1 Primary Antibody for IHC, WB - ABIN3023091
Liu, Chen, Pei, Zhang, Zou, Xiao, Zhou, Chen, Wang: Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. in Toxicology 2018
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Human Polyclonal NR3C1 Primary Antibody for IHC, WB - ABIN6673506
Zhang, Yao, Xiao, Lan, Yu, Zhang, Jiang, Yang, Pei, Li, Rong, Hu, Li, Xu: Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling. in International journal of clinical and experimental pathology 2014
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Human Monoclonal NR3C1 Primary Antibody for ICC, FACS - ABIN969321
Charmandari, Ichijo, Jubiz, Baid, Zachman, Chrousos, Kino: A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. in The Journal of clinical endocrinology and metabolism 2008
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Human Monoclonal NR3C1 Primary Antibody for ELISA, WB - ABIN2473809
Harris, Kerns, St Clair: RNA sulfurtransferase activity in rat liver and chemically induced hepatomas. in Cancer research 1976
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Human Polyclonal NR3C1 Primary Antibody for WB - ABIN2792573
: Triazolam Effects On Explicit Memory, Implicit Memory and Metamemory: Lister RG, Joyce EM, Weingartner HJ, Eckardt MJ Laboratory of Clinical Studies, NIAAA, DICBR, Bldg 10 Rm 3C102, 9000 Rockville Pike, Bethesda, MD 20892, USA. in Journal of psychopharmacology (Oxford, England) 2012
Human Polyclonal NR3C1 Primary Antibody for IF (p), IHC (p) - ABIN1713964
Ding, Shi, Han, Cui: Regulation of glucocorticoid-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats. in Life sciences 2016
Opn4m2 labeling shows nuclear localization, which did not change in response to light. opn4m1, opn4m2, gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
GR agonists enhanced, whereas GR loss diminished, Hematopoietic stem and progenitor cell formation.
Two distinct gene clusters were found that were regulated by GRalpha: one that was regulated by GRalpha under basal conditions (presence of endogenous cortisol only), and one that was regulated upon increased activation of GRalpha.
We suggest that GR controls a gene network required for visual adaptation in the zebrafish retina and potentially integrates neuroendocrine and sensory responses to environmental changes.
This study demonistrated that disruption of GR causes a syndrome in adult zebrafish that resembles an affective disorder.
GR signaling is essential for zebrafish muscle development
The maternal gr transcript and protein participate in the maternal programming of zebrafish development.
The present study demonstrates that in zebrafish a GR isoform exists that diverges from the canonical zebrafish GR at the same position as human GRbeta from human GRalpha.
epidermal GR and MR act cooperatively to regulate epidermal development and counteract skin inflammation.
These studies reveal a role of GR-HIF1alpha in regulating the metabolism and function of myeloid-derived suppressor cells.
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.
Glucocorticoid receptor displays no preference for a specific pro-inflammatory gene class; however, it effects repression by targeting distinct temporal events and components of transcriptional machinery.
The results of these in vivo and in vitro studies suggest that GR activation is associated with increased resistance against heat-induced hyperthermia and injury.
the glucocorticoid receptor (GR) drives steatosis in hypogonadal female mice because hepatocyte-specific GR knockout mice are refractory to developing ovariectomy-induced steatosis.
Fetal Nr3c1 heterozygosity leads to altered DNA methylation landscape in fetal placenta in a sex-specific manner. There was a significant overlap of differentially methylated genes in fetal placenta and adult frontal cortex in Nr3c1 heterozygotes. Phenotypically, Nr3c1 heterozygotes show significantly more anxiety-like behavior than wildtype.
our study shows that loss of podocyte GR worsens proteinuria in settings of injury, both in vivo and in vitro.
Results indicated that the effects of childhood trauma (CT)on mood may be mediated by GRalpha translational isoforms, which then could affect negative emotional states through direct and indirect paths involving full length GRalpha and FKBP5. The animal results demonstrated that 40-kDa GRalpha could be involved in fear extinction learning by affecting BDNF mRNA expression and neuronal plasticity in a sex-dependent manner.
These findings demonstrate that specific GR translational isoforms can influence development, circadian rhythm, and inflammation through the regulation of distinct gene networks.
APPL2 overexpression could blunt the activation of glucocorticoid receptor when undergoing environmental stress.
crosstalk between GCR and PPARgamma is largely synergistic but counter-regulatory in lipogenic genes, of which enhancement prevents excessive glycerol and possibly FFA release by glucocorticoids into the circulation.
Results provide compelling evidence that glucocorticoids and GR augment but are not required for the development of functional adipose tissue in vivo.
This work provides new findings inglucocorticoid (GC) field by bringing novel understanding on how GR integrates plasma membrane, allowing GC membrane-initiated signaling that differs in presence of GnRH to disrupt GnRH-dependent signaling and luteinizing hormone secretion.
The present study demonstrates the important role of GR in the regulation of the inflammatory responses and neurotrophic BDNF/TrkB signaling pathway in acute ischemic brain injuries in adult mice, revealing a new insight into the pathogenesis and therapeutic potential in acute ischemic strokes.
Absence of the GR significantly impairs fracture healing associated with a defective cartilage-to-bone transition.
Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver.
this study shows that selective ablation of GR in noradrenergic neurons does not affect fundamental properties of peritoneal leukocytes
Data (including data from studies in knockout/transgenic mice) suggest that, under hypoxic conditions, muscle atrophy and elevated gene expression of ubiquitin proteasomal system-associated enzymes are mostly independent of glucocorticoid/Nr3c1 signaling.
We propose that the GC-induced mitochondrial accumulation of Bax and the interaction between the GR and Bim, Bcl-xL and Bak could play a role in the regulation of thymocyte apoptosis.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 complex that favor FKBP51 repression over FKBP52 potentiation.
we showed that the dimerization state of the GRa influenced the post-translational processing of the receptor, specifically hyper-phosphorylation at Ser404, which influenced the interaction of GRalpha with the E3 ligase, FBXW7a, thus hampering receptor turnover via the proteasome
Study solved the crystal structure of glucocorticoid receptor (GR) DNA binding domain (DBD) in its DNA-free state, the first such crystal structure from any nuclear receptor, and revealed that DNA binding and dimerization drive conformational selection in the GR DBD lever arm region and show how DNA allosterically controls GR structure and dynamics.
The GR homodimer is essential for activating target gene transcription.
Examines relations between intra-individual differences in attachment and epigenetic modification of the oxytocin receptor (OXTR) and glucocorticoid receptor (NR3C1) gene promoter in 109 young adult human participants. Results revealed that attachment avoidance was significantly and specifically associated with increased OXTR and NR3C1 promoter methylation
Data show that glucocorticoid receptor (GR) expression is significantly decreased in primary prostate cancer tissue.
The potential contribution of NR3C1 polymorphisms to acute pain heterogeneity in sickle cell disease.
Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients
CCRP is essential for GR to form the N/C interaction
the rs6191 SNP was found to be associated with a reduced risk of attention deficit hyperactivity disorder (ADHD) in the dominant model while the rs25531 SNP was associated with an increased risk of ADHD in the multiplicative model. Additionally, both the rs6191 and rs25531 SNPs were significantly associated with the attention deficit factor but not with the hyperactivity/impulsivity factor
high levels of aldosterone in primary aldosteronism patients correlate with skin anomalies and inflammatory features associated with abnormal GR/MR activation in epidermal keratinocytes.
NR3C1 gene variation may be associated with Glucocorticoid resistance in pemphigus vulgaris patients.
These results suggest an association and crossed modulation between HO-1 and GR pathways.
GR gene polymorphism and occupational stress of desert petroleum workers were important risk factors for hypertension
High GR beta expression is associated with geriatric asthma.
in dyshidrotic eczema of palms and soles patients with genotype 646 CC, which are torpid to treatment, there is a complex of immune defense with the activation of complement system with activation of C3 and C4d
Study revealed that adverse pre- and postnatal environments, such as intrauterine growth restriction and postnatal relative adrenal insufficiency, increased glucocorticoid receptor gene methylation. This, in turn, may result in neurodevelopmental disabilities.
Glucocorticoid receptor beta mutation is associated with glucocorticoid hypersensitivity.
Strong and abundant expression of glucocorticoid receptor was observed in the submaxillary gland, kidney, and retroperitoneum of IgG4-related disease patients, while glucocorticoid receptor was rarely or only faintly observed in the submaxillary gland of patients with Sjogren's syndrome, radicular cysts and sialolithiasis or in the healthy kidney.
14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis.
In protein binding assays, GR inhibited the E2-induced interaction between ERalpha and FLII, suggesting that GR interferes with the binding of ERalpha and FLII at the ERalpha target genes, resulting in the release of ERalpha and FLII from estrogen responsive elements.
This study reveals the role of GR in muscle fiber inhibition on intramuscular adipocytes, and identifies myostatin as a muscle-derived modulator for adipose GR level.
These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
role in the breed-dependent regulation of mitochondrial genes in the liver of newborn piglets
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
Our results underscore a critical role for central and peripheral GR signaling in the regulation of plasma cortisol levels during stress in fish.
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs, but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma