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the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein (show RIPK1 Proteins) kinase (show CDK7 Proteins) 1 (RIP1 (show UQCRFS1 Proteins))-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues and demonstrate that RARgamma could promote HCC (show FAM126A Proteins) invasion and metastasis by regulating E-cadherin (show CDH1 Proteins) reduction.
Dual small interfering RNA (siRNA) silencing of RARalpha (show RARA Proteins) and RARgamma reversed RA blockade of P4-induced CK5 (show KRT5 Proteins). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (show KRT5 Proteins) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis.
A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers.
deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98 (show NUP98 Proteins)-RARG-mediated transformation
The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg (show PPARG Proteins) and RARs (show RARS Proteins), and there might be an association of PPARg (show PPARG Proteins)/RARs (show RARS Proteins)(RARa (show RARA Proteins), RARb (show RARB Proteins), and RARg) with renal diseases
RARgamma in concert with ATRA regulates protein levels of CDK1 (show CDK1 Proteins) and its subcellular localization.
RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene.
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 Proteins) signalling through physical interactions of RARs (show RARS Proteins) with beta-catenin (show CTNNB1 Proteins).
Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2 (show PPARG Proteins)) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation.
RARgamma plays key roles in the differentiation competence of NGN3 (show NEUROG3 Proteins)+ cells in response to retinoic acid during mouse spermatogenesis.
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha (show RARA Proteins) and RARgamma in bone structure regulation.
this study shows that the combination of Rarg and Nr5a2 (show NR5A2 Proteins) rapidly promote the iN cell maturation within 1 week and greatly facilitate the conversion with neuronal purities of approximately 50% and yields of >130%.
Data indicate that all three retinoic acid receptor (show RARA Proteins) isoforms RARalha, RARbeta (show RARB Proteins) and RARgamma are expressed in naive CD8 (show CD8A Proteins)+ T cells, as well as CD8 (show CD8A Proteins)+ T cells activated for 48 or 72 h.
erythroid-specific RAR (show RARA Proteins) function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis.
Data indicate that male germ cell specific miR (show MLXIP Proteins)-34c might be pivotal in embryonic stem cells (ESCs (show NR2E3 Proteins)) differentiation into male germ cells through its target retinoic acid receptor gamma (RARg).
RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis.
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
retinoic acid receptor, gamma
, retinoic acid receptor gamma-like
, retinoic acid receptor gamma
, nuclear receptor subfamily 1 group B member 3
, retinoic acid nuclear receptor gamma variant 1
, retinoic acid nuclear receptor gamma variant 2
, RAR gamma 2
, RAR-gamma 2.1
, rar gamma
, retinoic acid receptor gamma isoform 2.1