Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set
-
- Target See all AZGP1 products
- AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
- Reactivity
- Human
- Detection Method
- Colorimetric
- Host
- Mouse
- Method Type
- Sandwich ELISA
- Detection Range
- 0.0156 ng/mL - 1 ng/mL
- Minimum Detection Limit
- 0.0156 ng/mL
- Application
- ELISA
- Purpose
- Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set
- Sensitivity
- 100 pg/mL
- Characteristics
- Matched Pair Detection Set. Detects human Zinc-alpha-2-glycoprotein. Does not detect mouse Zinc-alpha-2-glycoprotein. Colorimetric assay. Sample Type: Cell Culture Supernatant, Plasma, Serum. Range: 0.0156 to 1 ng/mL. Sensitivity: 100 pg/mL. Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
- Components
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
-
- Restrictions
- For Research Use only
-
- Concentration
- Lot specific
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
-
Short Term Storage: -20°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
-
- Target
- AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
- Alternative Name
- Zinc-alpha-2-glycoprotein (AZGP1 Products)
- Synonyms
- Zag Matched Antibody Pair, ZA2G Matched Antibody Pair, ZAG Matched Antibody Pair, ZA2GA Matched Antibody Pair, Zna2gp Matched Antibody Pair, alpha-2-glycoprotein 1, zinc Matched Antibody Pair, alpha-2-glycoprotein 1, zinc-binding Matched Antibody Pair, Azgp1 Matched Antibody Pair, AZGP1 Matched Antibody Pair
- Background
-
Alternate Names/Synonyms: Zn-alpha-2-GP, Zn-alpha-2-Glycoprotein, ZAG, ZA2G, AZGP1, ZNGP1
Product Description: Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
-
