Breast Cancer 1 (BRCA1) (N-Term) Peptide
BRCA1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BRCA1 products
- BRCA1 (Breast Cancer 1 (BRCA1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DLSALRVEEV QNVINAMQKI LECPICLELI KEPVSTKCDH IFCKFCMLKL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BRCA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BRCA1 (Breast Cancer 1 (BRCA1))
- Synonyms
- BRCAI Peptide, BRCC1 Peptide, BROVCA1 Peptide, IRIS Peptide, PNCA4 Peptide, PPP1R53 Peptide, PSCP Peptide, RNF53 Peptide, iris Peptide, pscp Peptide, brcai Peptide, brcc1 Peptide, rnf53 Peptide, brca1 Peptide, BRCA1 Peptide, LOC100224649 Peptide, BRCA1, DNA repair associated Peptide, breast cancer 1 Peptide, breast cancer 1, early onset Peptide, breast cancer 1 L homeolog Peptide, BRCA1 Peptide, brca1 Peptide, LOC755086 Peptide, Brca1 Peptide, brca1.L Peptide
- Background
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BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45 % of inherited breast cancer and more than 80 % of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.
Alias Symbols: BRCAI, BRCC1, IRIS, PSCP, RNF53, PNCA4, BROVCA1, PPP1R53
Protein Size: 680 - Molecular Weight
- 76 kDa
- Gene ID
- 672
- NCBI Accession
- NM_007298, NP_009229
- UniProt
- P38398
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