EPH Receptor A5 (EPHA5) Peptide
EPHA5
Reactivity: Mouse, Rat
Host: Synthetic
BP, WB, ICo, IDe
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- Target See all EPH Receptor A5 (EPHA5) products
- EPH Receptor A5 (EPHA5)
- Peptide Type
- Synthetic
- Origin
- Mouse, Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunocompetition (ICo), Immunodepletion (IDe)
- Purification
- Synthetic Peptide
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Storage
- -20 °C
- Storage Comment
- For long-term storage of keep at -20 °C.
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- Target
- EPH Receptor A5 (EPHA5)
- Synonyms
- CEK7 Peptide, EHK-1 Peptide, EHK1 Peptide, EK7 Peptide, HEK7 Peptide, TYRO4 Peptide, AI854630 Peptide, AW125296 Peptide, Cek7 Peptide, Ehk1 Peptide, Els1 Peptide, Hek7 Peptide, Rek7 Peptide, bsk Peptide, Els1. Peptide, EPHA5 Peptide, EPH receptor A5 Peptide, Eph receptor A5 Peptide, EPHA5 Peptide, epha5 Peptide, Epha5 Peptide
- Background
- The Ephrin receptors represent the largest group of Receptor Tyrosine Kinases, comprising of 14 members and divided in two subclasses (class A & B ephrin ligands) based on their abilities to bind and activate each other, and on sequence conservation. Ephrin-A (EFNA) class is anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) classes are trans-membrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrins interact with a variety of membrane receptors that respond to chemokines, neurotransmitters or growth factors. Eph receptors are involved in central nervous system function and development, and in the modulation of different types of nociception. Eph receptors and their ligands play important roles in the regulation of cancer cell migration and invasion and are key regulators of axon guidance. They function in a variety of signaling modes by transducing signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. Ephrin A5, a member of the ephrin family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. Ephrin-A5 is highly expressed in the developing nervous system in several brain regions including the olfactory bulb, frontal cortex, striatum and hypothalamus. Ephrin-A5 acts as a guidance molecule regulating the trajectory of the ascending midbrain dopaminergic pathways. Ephrin- A5 expression is critical for proper development of central monoaminergic pathways and that its loss results in various neurodevelopmental abnormalities. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and mediate developmental events in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EphrinA5 possesses two alternative isoforms, large ephrinA5 isoform (ephrinA5L) and small ephrinA5 isoform (ephrinA5S). EphrinA5L is a putative tumor suppressor in several types of human cancers and ephrin A5S, acts as a tumor suppressor specifically in human hepatocellular carcinomas (HCC).The gene for EphA R5 is present on chromosome 5q21
- NCBI Accession
- NP_004430
- UniProt
- P54756
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