Gly-Arg-Gly-Asp-Asn-Pro Peptide
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- Target
- Gly-Arg-Gly-Asp-Asn-Pro
- Purity
- > 95 %
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- Restrictions
- For Research Use only
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- Storage
- -20 °C
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- Target
- Gly-Arg-Gly-Asp-Asn-Pro
- Target Type
- Peptide
- Background
- G-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM.
- CAS-No
- 114681-65-1
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