Fibroblast Growth Factor Receptor 4 (FGFR4) (Middle Region) Peptide
FGFR4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FGFR4 products
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LITGDSLTSS NDDEDPKSHR DPSNRHSYPQ QAPYWTHPQR MEKKLHAVPA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- FGFR4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Synonyms
- FGFR4 Peptide, XFGFR-4 Peptide, XFGFR-4a Peptide, cd334 Peptide, fgfr-4 Peptide, jtk2 Peptide, tkf Peptide, xfgfr4 Peptide, CD334 Peptide, JTK2 Peptide, TKF Peptide, Fgfr-4 Peptide, etID309818.21 Peptide, wu:fc13h10 Peptide, zgc:111935 Peptide, fgfr-4c Peptide, fgfr4 Peptide, fibroblast growth factor receptor 4 Peptide, fibroblast growth factor receptor 4 S homeolog Peptide, FGFR4 Peptide, fgfr4 Peptide, Fgfr4 Peptide, fgfr4.S Peptide
- Background
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The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Alias Symbols: TKF, JTK2, CD334
Protein Size: 762 - Gene ID
- 2264
- NCBI Accession
- NM_001291980, NP_002002
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