MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (N-Term) Peptide
MKNK2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MKNK2 products
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SQPIDIPDAK KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MKNK2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
- Synonyms
- GPRK7 Peptide, MNK2 Peptide, gprk7 Peptide, mnk2 Peptide, 2010016G11Rik Peptide, Gprk7 Peptide, Mnk2 Peptide, mknk2 Peptide, wu:fb37e05 Peptide, wz5090 Peptide, fi34c11 Peptide, wu:fi34c11 Peptide, wu:fi41e12 Peptide, zgc:55587 Peptide, MAP kinase interacting serine/threonine kinase 2 Peptide, MAP kinase-interacting serine/threonine kinase 2 Peptide, MAP kinase interacting serine/threonine kinase 2b Peptide, MAP kinase interacting serine/threonine kinase 2 L homeolog Peptide, MAP kinase interacting serine/threonine kinase 2a Peptide, MKNK2 Peptide, mknk2 Peptide, Mknk2 Peptide, mknk2b Peptide, mknk2.L Peptide, mknk2a Peptide
- Background
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This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.
Alias Symbols: MKNK2,GPRK7, MNK2,
Protein Size: 414 - Gene ID
- 2872
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