WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) Peptide
WWTR1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all WWTR1 products
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-WWTR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- Synonyms
- WWTR1 Peptide, TAZ Peptide, 2310058J06Rik Peptide, 2610021I22Rik Peptide, C78399 Peptide, Taz Peptide, WW domain containing transcription regulator 1 L homeolog Peptide, WW domain containing transcription regulator 1 Peptide, wwtr1.L Peptide, wwtr1 Peptide, WWTR1 Peptide, Wwtr1 Peptide
- Background
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WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. It regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. And it regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Alias Symbols: WWTR1,TAZ,
Protein Size: 400 - Gene ID
- 25937
- NCBI Accession
- NP_056287
- UniProt
- Q9GZV5
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