Chromosome 14 Open Reading Frame 49 (C14orf49) (N-Term) Peptide
C14orf49
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Nesprin3 (C14orf49) products
- Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AQVLLHNVDN QAVLLDRLLE EAASLFNRIG DPSVDEDAQK RMKAEYDAVK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SYNE3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))
- Synonyms
- C14orf49 Peptide, NET53 Peptide, Nesp3 Peptide, 4831426I19Rik Peptide, nesprin-3 Peptide, spectrin repeat containing nuclear envelope family member 3 Peptide, spectrin repeat containing, nuclear envelope family member 3 Peptide, SYNE3 Peptide, Syne3 Peptide
- Background
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SYNE3 is a component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. It is involved in the maintenance of nuclear organization and structural integrity. It is a probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. SYNE3 plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Protein Size: 596 - Gene ID
- 161176
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