Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) (Middle Region) Peptide
INPP5E
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all INPP5E products
- INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SLQEIPKSRG VLSSERGSPS SGGNPLSGVA SSSPNLPHRD AAVAGSSPRL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- INPP5E Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))
- Synonyms
- 1200002L24Rik Peptide, 72kDa Peptide, mKIAA0123 Peptide, CORS1 Peptide, CPD4 Peptide, JBTS1 Peptide, MORMS Peptide, PPI5PIV Peptide, PMPCA Peptide, inositol polyphosphate-5-phosphatase E Peptide, Inpp5e Peptide, INPP5E Peptide
- Background
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The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome, a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: CPD4, CORS1, JBTS1, MORMS, PPI5PIV
Protein Size: 610 - Gene ID
- 56623
- NCBI Accession
- NM_019892, NP_063945
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