DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (Middle Region) Peptide
DFFA
Reactivity: Human
Host: Synthetic
WB
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- Target See all DFFA products
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- DYFLCLPSNT KFVALASNEK WAYNNSDGGT AWISQESFDV DETDSGAGLK
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Synonyms
- DFF-45 Peptide, DFF1 Peptide, ICAD Peptide, A330085O09Rik Peptide, DFF35 Peptide, Dff45 Peptide, ICAD-L Peptide, ICAD-S Peptide, DFFA Peptide, zgc:92229 Peptide, DNA fragmentation factor subunit alpha Peptide, DNA fragmentation factor, alpha subunit Peptide, DNA fragmentation factor, 45kDa, alpha polypeptide Peptide, DNA fragmentation factor, alpha polypeptide Peptide, DFFA Peptide, Dffa Peptide, dffa Peptide
- Background
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Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFF1, ICAD, DFF-45,
Protein Size: 167 - Gene ID
- 1676
- NCBI Accession
- NM_004401, NP_004392
- UniProt
- O00273
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