Pancreatic and Duodenal Homeobox 1 (PDX1) (Middle Region) Peptide
PDX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PDX1 products
- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- FQNRRMKWKK EEDKKRGGGT AVGGGGVAEP EQDCAVTSGE ELLALPPPPP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PDX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
- Synonyms
- GSF Peptide, IDX-1 Peptide, IPF1 Peptide, IUF1 Peptide, MODY4 Peptide, PDX-1 Peptide, STF-1 Peptide, ipf1 Peptide, PDX1 Peptide, IPF-1 Peptide, Ipf1 Peptide, Mody4 Peptide, pdx-1 Peptide, Idx1 Peptide, Stf1 Peptide, zgc:100874 Peptide, XlHbox-8 Peptide, xlhbox8 Peptide, pancreatic and duodenal homeobox 1 Peptide, pancreatic and duodenal homeobox 1 S homeolog Peptide, PDX1 Peptide, pdx1 Peptide, Pdx1 Peptide, pdx1.S Peptide
- Background
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The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Alias Symbols: GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, PAGEN1
Protein Size: 283 - Gene ID
- 3651
- NCBI Accession
- NM_000209, NP_000200
- UniProt
- P52945
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