Chromosome 10 Open Reading Frame 2 (C10ORF2) (C-Term) Peptide
C10ORF2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all C10orf2 (C10ORF2) products
- C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KARLKKIKDD TGPVAKKPSS GKKGATTQNS EICSGQAPTP DQPDTSKRSK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PEO1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))
- Synonyms
- ATXN8 Peptide, IOSCA Peptide, MTDPS7 Peptide, PEO Peptide, PEO1 Peptide, PEOA3 Peptide, SANDO Peptide, SCA8 Peptide, TWINL Peptide, C6H10orf2 Peptide, D19Ertd626e Peptide, Twinl Peptide, twinkle mtDNA helicase L homeolog Peptide, twinkle mtDNA helicase Peptide, twnk.L Peptide, TWNK Peptide, Twnk Peptide
- Background
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This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: PEO, PEO1, SCA8, ATXN8, IOSCA, PEOA3, SANDO, TWINL, MTDPS7, PRLTS5, C10orf2
Protein Size: 684 - Gene ID
- 56652
- NCBI Accession
- NM_001163812, NP_001157284
- UniProt
- Q96RR1
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