C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Middle Region) Peptide
ABL1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ABL1 products
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SKAGSGAPGG TSKGPAEESR VRRHKHSSES PGRDKGKLSR LKPAPPPPPA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- ABL1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- Synonyms
- ABL Peptide, JTK7 Peptide, bcr/abl Peptide, c-ABL Peptide, p150 Peptide, v-abl Peptide, AI325092 Peptide, Abl Peptide, E430008G22Rik Peptide, c-Abl Peptide, ABL proto-oncogene 1, non-receptor tyrosine kinase Peptide, c-abl oncogene 1, non-receptor tyrosine kinase Peptide, Tyrosine-protein kinase abl-1 Peptide, ABL1 Peptide, Abl1 Peptide, abl-1 Peptide, abl1 Peptide
- Background
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This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9,22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Alias Symbols: ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl
Protein Size: 1130 - Gene ID
- 25
- NCBI Accession
- NM_005157, NP_005148
- UniProt
- P00519
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