Caspase 12 (Gene/pseudogene) (CASP12) (Middle Region) Peptide
CASP12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Caspase 12 (CASP12) products
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LGMRDLLENL GYSVVIKENL TAQEMETALR QFAAHPEHQS SDSTFLVFMS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- CASP12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
- Synonyms
- Caspase-12 Peptide, CASP-12 Peptide, CASP12P1 Peptide, caspase 12 Peptide, caspase 12 (gene/pseudogene) Peptide, Casp12 Peptide, CASP12 Peptide
- Background
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Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
Alias Symbols: CASP-12, CASP12P1
Protein Size: 257 - Gene ID
- 100506742
- NCBI Accession
- NM_001191016, NP_001177945
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