Adrenocortical Dysplasia Homolog (ACD) (C-Term) Peptide
ACD
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all ACD products
- ACD (Adrenocortical Dysplasia Homolog (ACD))
- Protein Region
- C-Term
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Acd Antibody(ARP36813_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ACD (Adrenocortical Dysplasia Homolog (ACD))
- Synonyms
- PIP1 Peptide, PTOP Peptide, TINT1 Peptide, TPP1 Peptide, ACD Peptide, ACD, shelterin complex subunit and telomerase recruitment factor Peptide, adrenocortical dysplasia Peptide, ACD Peptide, Acd Peptide
- Background
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Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.
Alias Symbols: -
Protein Size: 416 - Molecular Weight
- 45 kDa
- Gene ID
- 497652
- NCBI Accession
- NM_001012638, NP_001012656
- UniProt
- Q5EE38
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