Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) Peptide
BRE
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BRE products
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- Protein Region
- C-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK RAKAYFKTFV PQFQEAAFAN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BRE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- Synonyms
- brcc4 Peptide, brcc45 Peptide, BRE Peptide, LOC100231620 Peptide, BRCC4 Peptide, BRCC45 Peptide, 6030405P19Rik Peptide, AI429776 Peptide, B830038C02Rik Peptide, im:7141046 Peptide, zgc:110368 Peptide, BRISC and BRCA1 A complex member 2 Peptide, brain and reproductive organ-expressed (TNFRSF1A modulator) Peptide, BRISC and BRCA1 A complex member 2 L homeolog Peptide, babam2 Peptide, BABAM2 Peptide, Babam2 Peptide, BRE Peptide, babam2.L Peptide
- Background
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BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: BABAM1,GFI1B,ATG2A,BABAM1,BARD1,BRCA1,BRCA2,BRCC3,COPS5,DHRS7B,FAM175A,FAM175B,FAS,FKBP8,LRPPRC,MMS19,NCOA3,PHB,RAD51,RPN2,SHMT2,SLC25A13,SSR3,SUMO1,TMX3,TNFRSF1A,TP53,TTC28,UBC,UBE2D1,UGGT2,UIMC1,USP7
Protein Size: 383 - Molecular Weight
- 43 kDa
- Gene ID
- 9577
- NCBI Accession
- NM_199194, NP_954664
- UniProt
- Q9NXR7
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