beta-Transducin Repeat Containing (BTRC) (C-Term) Peptide
BTRC
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all BTRC products
- BTRC (beta-Transducin Repeat Containing (BTRC))
- Protein Region
- C-Term
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Btrc Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BTRC (beta-Transducin Repeat Containing (BTRC))
- Synonyms
- BTRC Peptide, Beta-TrCP Peptide, betaTrCP Peptide, btrcp Peptide, btrcp1 Peptide, fbw1a Peptide, fbxw1 Peptide, fbxw1a Peptide, fwd1 Peptide, btrc Peptide, beta-TrCP Peptide, BETA-TRCP Peptide, FBW1A Peptide, FBXW1 Peptide, FBXW1A Peptide, FWD1 Peptide, bTrCP Peptide, bTrCP1 Peptide, beta-TrCP1 Peptide, btrc-a Peptide, Beta-Trcp1 Peptide, Fbw1a Peptide, HOS Peptide, Slimb Peptide, b-TrCP Peptide, mKIAA4123 Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase Peptide, beta-transducin repeat containing Peptide, beta-TrCP Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog Peptide, beta-transducin repeat containing protein Peptide, BTRC Peptide, btrc Peptide, LOC100634006 Peptide, Btrc Peptide, btrc.S Peptide
- Background
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Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Size: 605 - Molecular Weight
- 69 kDa
- Gene ID
- 12234
- NCBI Accession
- NM_001037758, NP_001032847
- UniProt
- Q3ULA2
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