Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1) (N-Term) Peptide
CALCOCO1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CALCOCO1 products
- CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))
- Protein Region
- N-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CALCOCO1 Antibody(ARP57483_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))
- Synonyms
- Cocoa Peptide, calphoglin Peptide, fa11a10 Peptide, wu:fa11a10 Peptide, CALCOCO1 Peptide, Xdsg Peptide, cocoa Peptide, dsgc Peptide, pp13275 Peptide, 1810009B06Rik Peptide, Gcap11 Peptide, mKIAA1536 Peptide, calcium binding and coiled-coil domain 1 Peptide, calcium binding and coiled-coil domain 1a Peptide, calcium binding and coiled-coil domain 1 S homeolog Peptide, calcium binding and coiled-coil domain 1 L homeolog Peptide, calcium binding and coiled coil domain 1 Peptide, CALCOCO1 Peptide, calcoco1a Peptide, calcoco1.S Peptide, calcoco1.L Peptide, Calcoco1 Peptide
- Background
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CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
Alias Symbols: Cocoa, KIAA1536, PP13275, calphoglin
Protein Interaction Partner: APTX,CREBBP,CRYBA2,CTNNBL1,CYTH3,EP300,FOSL1,IPP,KRT15,MAPK1,NDC80,SH3GL3,TBC1D17,MAPK1,CRYBA2,CYTH3,FOSL1,KRT15,NDC80,SH3GL3,TBC1D17
Protein Size: 691 - Molecular Weight
- 77 kDa
- Gene ID
- 57658
- NCBI Accession
- NM_020898, NP_065949
- UniProt
- Q9P1Z2
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