Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2) (N-Term) Peptide
CAMKK2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CAMKK2 products
- CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CAMKK2 antibody (Catalog #: ARP53184_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))
- Synonyms
- CAMKK Peptide, CAMKKB Peptide, 6330570N16Rik Peptide, AW061083 Peptide, mKIAA0787 Peptide, camk2b Peptide, fj90d04 Peptide, wu:fj90d04 Peptide, si:dkey-174n20.2 Peptide, CAMKK2 Peptide, calcium/calmodulin dependent protein kinase kinase 2 Peptide, calcium/calmodulin-dependent protein kinase kinase 2, beta Peptide, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 Peptide, calcium/calmodulin dependent protein kinase II beta Peptide, calcium/calmodulin-dependent protein kinase kinase 2 Peptide, CAMKK2 Peptide, Camkk2 Peptide, camk2b1 Peptide, CAMK2B Peptide, camkk2 Peptide
- Background
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CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.
Alias Symbols: CAMKK, CAMKKB, KIAA0787, MGC15254
Protein Interaction Partner: CALM1,CAMK1,CAMK4,CAMK1,PRKACA,SGK1
Protein Size: 498 - Molecular Weight
- 55 kDa
- Gene ID
- 10645
- NCBI Accession
- NM_153500, NP_705720
- UniProt
- Q96RR4
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