V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) (C-Term) Peptide
CRK
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Crk (CRK) products
- Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IPVPYVEKYR PASASVSALI GGNQEGSHPQ PLGGPEPGPY AQPSVNTPLP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CRK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
- Synonyms
- CG1587 Peptide, CRK Peptide, D-CRK Peptide, D-Crk Peptide, DCrk Peptide, Dcrk Peptide, Dmel\\CG1587 Peptide, crk Peptide, dCRK Peptide, dCrk Peptide, fb34h10 Peptide, fc05a01 Peptide, fi19g05 Peptide, wu:fb34h10 Peptide, wu:fc05a01 Peptide, wu:fc54a04 Peptide, wu:fi19g05 Peptide, zgc:100936 Peptide, CRKII Peptide, p38 Peptide, Crko Peptide, crk2 Peptide, crkII Peptide, v-crk Peptide, P38C-CRK Peptide, Crk-I Peptide, Crk-II Peptide, Crk-III Peptide, Crk3 Peptide, CrkIII Peptide, c-Crk Peptide, Crk oncogene Peptide, v-crk avian sarcoma virus CT10 oncogene homolog Peptide, CRK proto-oncogene, adaptor protein Peptide, v-crk avian sarcoma virus CT10 oncogene homolog L homeolog Peptide, v-crk sarcoma virus CT10 oncogene homolog Peptide, Crk Peptide, crk Peptide, CRK Peptide, crk.L Peptide
- Background
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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Alias Symbols: CRKII, p38
Protein Interaction Partner: ZAP70,MAP4K1,ABL1,ABL2,ABL2,PDGFRB,ZAP70,ABL1,ABL2,ARHGAP32,ATXN1,AVIL,BCAR1,BCR,BUB1,CBL,CBLC,CRKL,DAB1,DOCK1,DOCK3,DOK4,DPPA4,EGFR,EPHA3,EPHB3,EPHB6,EPS15,ERBB4,FGFR1,FLT1,FRS2,FYN,GAB1,GRB2,IGF1R,INSR,IRS1,IRS2,IRS4,KDR,KIT,MAP4K1,MAP4K5,MAPK8,NCK1,NED
Protein Size: 304 - Molecular Weight
- 34 kDa
- Gene ID
- 1398
- NCBI Accession
- NM_016823, NP_058431
- UniProt
- P46108
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