Glutaredoxin 2 (GRX2) (Middle Region) Peptide
GRX2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Glutaredoxin 2 (GRX2) products
- Glutaredoxin 2 (GRX2)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GLRX2 Antibody(ARP57792_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Glutaredoxin 2 (GRX2)
- Synonyms
- ECK1049 Peptide, JW1051 Peptide, CGI-133 Peptide, GRX2 Peptide, 1700010P22Rik Peptide, AI645710 Peptide, Grx2 Peptide, glutaredoxin 2 (Grx2) Peptide, glutaredoxin Grx2 Peptide, thioredoxin Peptide, glutaredoxin 2 Peptide, glutaredoxin 2 (thioltransferase) Peptide, grxB Peptide, grx2 Peptide, AF_RS10790 Peptide, GLRX2 Peptide, Glrx2 Peptide
- Background
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GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Alias Symbols: GRX2, bA101E13.1, CGI-133
Protein Interaction Partner: TXNRD1,TXNRD1
Protein Size: 164 - Molecular Weight
- 18 kDa
- Gene ID
- 51022
- NCBI Accession
- NM_197962, NP_932066
- UniProt
- Q9NS18
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