Serotonin Receptor 1B (HTR1B) Peptide
HTR1B
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all 5HT1B Receptor (HTR1B) products
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HTR1B antibody (Catalog #: AVARP13042_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
- Synonyms
- 5-HT1B Peptide, 5-HT1DB Peptide, HTR1D2 Peptide, HTR1DB Peptide, S12 Peptide, 5-HT1Db Peptide, 5-HT1-LIKE Peptide, HTR1B Peptide, 5-HT-dro2B Peptide, 5-HT1BDro Peptide, 5-HT[1B]Dro Peptide, 5-HT[[1BDro]] Peptide, 5-HT[[1B]] Peptide, 5-HT[[1B]]DRO Peptide, 5-HT[[1B]]Dro Peptide, 5-HT[[dro2B]] Peptide, 5HT-R2B Peptide, 5HT-dro2B Peptide, 5HT-dro[[2B]] Peptide, 5HT1B Peptide, 5htdro2b Peptide, CG15113 Peptide, CG30126 Peptide, DRO2B Peptide, Dm5HTdro2B Peptide, Dmel\\CG15113 Peptide, Dmel_CG30126 Peptide, d5-HT1B Peptide, 5-HT-1B Peptide, zgc:194666 Peptide, zgc:194690 Peptide, 5-hydroxytryptamine receptor 1B Peptide, 5-hydroxytryptamine (serotonin) receptor 1B Peptide, HTR1B Peptide, Htr1b Peptide, 5-HT1B Peptide, htr1b Peptide
- Background
-
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Alias Symbols: S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Protein Interaction Partner: HTR1A,HTR1B,HTR1D,HTR1A,HTR1B,HTR1D,GSTK1,HTR1D,NME2
Protein Size: 390 - Molecular Weight
- 44 kDa
- Gene ID
- 3351
- NCBI Accession
- NM_000863, NP_000854
- UniProt
- P28222
-
You are here:
