LIM Homeobox Transcription Factor 1, alpha (LMX1A) Peptide
LMX1A
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all LMX1A products
- LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-LMX1A antibody (Catalog #: ARP31999_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))
- Synonyms
- Lmx1.1 Peptide, dr Peptide, dreher Peptide, sst Peptide, LMX1 Peptide, LMX1.1 Peptide, si:ch211-260g14.3 Peptide, LIM homeobox transcription factor 1 alpha Peptide, LIM homeobox transcription factor 1, alpha Peptide, Lmx1a Peptide, LMX1A Peptide, lmx1a Peptide
- Background
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Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c
Alias Symbols: LMX-1, LMX1, LMX1.1, MGC87616
Protein Interaction Partner: BMPR2,ISL1,LDB1,ISL1,LHX3,LMX1A,TCF3
Protein Size: 382 - Molecular Weight
- 43 kDa
- Gene ID
- 4009
- NCBI Accession
- NM_177398, NP_796372
- UniProt
- Q8TE12
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