Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (Middle Region) Peptide
NFX1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all NFX1 products
- NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NFX1 antibody (Catalog #: P100680_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))
- Synonyms
- NFX1 Peptide, NFX2 Peptide, 1300017N15Rik Peptide, 3000003M19Rik Peptide, NFX.1 Peptide, TEG-42 Peptide, Tex42 Peptide, nuclear transcription factor, X-box binding 1 Peptide, nuclear transcription factor, x-box binding 1 Peptide, NFX1 Peptide, CpipJ_CPIJ011986 Peptide, nfx1 Peptide, Nfx1 Peptide
- Background
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MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Alias Symbols: DKFZp779G2416, MGC20369, NFX2
Protein Interaction Partner: ELAVL4,NUP153,NUP214,NUP62,NUP98
Protein Size: 1120 - Molecular Weight
- 124 kDa
- Gene ID
- 4799
- NCBI Accession
- NM_002504, NP_002495
- UniProt
- Q12986
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