Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) Peptide
NR0B2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NR0B2 products
- NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NR0B2 antibody (Catalog #: ARP36012_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))
- Synonyms
- SHP Peptide, SHP1 Peptide, SHP-1 Peptide, Shp1 Peptide, Shp Peptide, NR0B2-A Peptide, Nr0b2 Peptide, SHP-A Peptide, gb:bc058069 Peptide, nuclear receptor subfamily 0 group B member 2 Peptide, nuclear receptor subfamily 0, group B, member 2 Peptide, nuclear receptor subfamily 0, group B, member 2a Peptide, NR0B2 Peptide, Nr0b2 Peptide, nr0b2a Peptide
- Background
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NR0B2 is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. It is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: SHP, SHP1
Protein Interaction Partner: NR5A2,AR,DDX20,EID1,ESR1,ESR2,ESRRA,ESRRG,HNF4A,HNF4G,NR1H2,NR1H3,NR1I3,NR5A2,PPARD,PPARG,RARA,RARG,RXRA,RXRB,SNW1,VDR,AR,ESR1,HNF4A,NCOA3,NR1H2,NR1H3,NR5A2,POLR2A,PPARG,RARA,RXRA,RXRG,THRA
Protein Size: 257 - Molecular Weight
- 28 kDa
- Gene ID
- 8431
- NCBI Accession
- NM_021969, NP_068804
- UniProt
- Q15466
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