Optineurin (OPTN) (N-Term) Peptide
OPTN
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all OPTN products
- OPTN (Optineurin (OPTN))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-OPTN antibody (Catalog #: ARP32292_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- OPTN (Optineurin (OPTN))
- Synonyms
- nrp Peptide, fip2 Peptide, hip7 Peptide, hypl Peptide, glc1e Peptide, tfiiia-intp Peptide, ALS12 Peptide, FIP2 Peptide, GLC1E Peptide, HIP7 Peptide, HYPL Peptide, NRP Peptide, TFIIIA-INTP Peptide, Fip2 Peptide, 4930441O07Rik Peptide, fj52f04 Peptide, si:ch211-240l19.3 Peptide, wu:fj52f04 Peptide, zgc:66386 Peptide, zgc:77868 Peptide, optineurin Peptide, optineurin L homeolog Peptide, OPTN Peptide, optn Peptide, Optn Peptide, optn.L Peptide
- Background
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OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, ALS12
Protein Interaction Partner: HTT,RAB8A,CCDC53,FLII,FOS,GTF3A,HTT,RAB11B,RAB8A,RNF11,TBC1D17,CCDC53,HTT,RAB8A,TBC1D17,WDR20
Protein Size: 577 - Molecular Weight
- 66 kDa
- Gene ID
- 10133
- NCBI Accession
- NM_001008213, NP_001008214
- UniProt
- Q96CV9
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