Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (Middle Region) Peptide
P2RX7
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all P2RX7 products
- P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-P2RX7 antibody (Catalog #: ARP35112_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
- Synonyms
- p2xr7 Peptide, P2RX7 Peptide, P2X7 Peptide, AI467586 Peptide, P2X(7) Peptide, P2X7R Peptide, p2x7 Peptide, purinergic receptor P2X 7 Peptide, purinergic receptor P2X, ligand-gated ion channel, 7 Peptide, P2X purinoceptor 7 Peptide, P2RX7 Peptide, p2rx7 Peptide, LOC100458463 Peptide, P2rx7 Peptide
- Background
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The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC20089, P2X7
Protein Interaction Partner: ACTB,EMP3,PANX1,SVIL
Protein Size: 595 - Molecular Weight
- 68 kDa
- Gene ID
- 5027
- NCBI Accession
- NM_002562, NP_002553
- UniProt
- Q99572
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