Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12) (N-Term) Peptide
PSMD12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PSMD12 products
- PSMD12 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSMD12 Antibody(ARP57839_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PSMD12 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12))
- Synonyms
- wu:fb38a06 Peptide, wu:fc34f08 Peptide, wu:fc49f02 Peptide, PSMD12 Peptide, rpn5 Peptide, Rpn5 Peptide, p55 Peptide, 1500002F15Rik Peptide, AI480719 Peptide, P55 Peptide, proteasome 26S subunit, non-ATPase 12 Peptide, proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Peptide, psmd12 Peptide, PSMD12 Peptide, Psmd12 Peptide
- Background
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.
Alias Symbols: MGC75406, p55, Rpn5
Protein Interaction Partner: PSMD13,TRAF6,PAAF1,PSMD10,PSMD13,PSMD14,PSMD6,PSMD7,TRAF6,UCHL5,USP14,USP20
Protein Size: 456 - Molecular Weight
- 50 kDa
- Gene ID
- 5718
- NCBI Accession
- NM_002816, NP_002807
- UniProt
- O00232
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