Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (N-Term) Peptide
PTPN11
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all PTPN11 products
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- HPGDFVLSVR TGDDKGESND GKSKVTHVMI RCQELKYDVG GGERFDSLTD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTPN11 Antibody(ARP56494_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- Synonyms
- BPTP3 Peptide, CFC Peptide, NS1 Peptide, PTP-1D Peptide, PTP2C Peptide, SH-PTP2 Peptide, SH-PTP3 Peptide, SHP2 Peptide, 2700084A17Rik Peptide, AW536184 Peptide, PTP1D Peptide, SAP-2 Peptide, SHP-2 Peptide, Shp2 Peptide, Syp Peptide, SYP Peptide, bptp3 Peptide, cfc Peptide, ns1 Peptide, ptp-2 Peptide, ptp2c Peptide, ptpn11 Peptide, ptpn11-a Peptide, ptpn11-b Peptide, shp-2 Peptide, shp2 Peptide, fa14b09 Peptide, wu:fa14b09 Peptide, wu:fi24f03 Peptide, zgc:55388 Peptide, zgc:63553 Peptide, protein tyrosine phosphatase, non-receptor type 11 Peptide, protein tyrosine phosphatase, non-receptor type 11 S homeolog Peptide, protein tyrosine phosphatase, non-receptor type 11, a Peptide, protein tyrosine phosphatase, non-receptor type 11, b Peptide, PTPN11 Peptide, Ptpn11 Peptide, ptpn11.S Peptide, ptpn11a Peptide, ptpn11b Peptide
- Target Type
- Viral Protein
- Background
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Alias Symbols: BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Protein Interaction Partner: BCR,CAT,CAV1,FLT1,GAB1,GRB2,KIT,PDGFRB,PDGFRB,SLAMF1,cagA,ACTN4,ARHGAP1,AXL,BCR,BDKRB2,BTLA,C6orf25,CAT,CAV1,CBL,CCKBR,CD33,CDH5,CEACAM1,CHUK,CRKL,CSF2RB,CSF3R,CTLA4,CXCR4,DAB1,DDR1,EGFR,EPHA2,EPOR,ERBB2,FLT1,FLT4,FRS2,FRS3,FYN,GAB1,GAB2,GAB3,GHR,GRB2,GRI
Protein Size: 593 - Molecular Weight
- 68 kDa
- Gene ID
- 5781
- NCBI Accession
- NM_002834, NP_002825
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