Premelanosome Protein (PMEL) Peptide
PMEL
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all Melanoma gp100 (PMEL) products
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SILV antibody (Catalog #: ARP46802_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Synonyms
- D12S53E Peptide, ME20 Peptide, ME20-M Peptide, ME20M Peptide, P1 Peptide, P100 Peptide, PMEL17 Peptide, SI Peptide, SIL Peptide, SILV Peptide, gp100 Peptide, D10H12S53E Peptide, D12S53Eh Peptide, Pmel17 Peptide, Si Peptide, Silv Peptide, gp87 Peptide, RPE1 Peptide, MMP115 Peptide, silverb Peptide, silver Peptide, cb397 Peptide, fdv Peptide, pmel17 Peptide, sb:cb397 Peptide, silva Peptide, wu:fc11g11 Peptide, wu:fj24g11 Peptide, zgc:136622 Peptide, premelanosome protein Peptide, premelanosome protein b Peptide, premelanosome protein a Peptide, PMEL Peptide, Pmel Peptide, pmelb Peptide, pmela Peptide
- Background
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SILV could be a melanogenic enzyme. It could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, it could protect tumor cells from antibody mediated immunity.
Alias Symbols: D12S53E, ME20, PMEL17, SI, SIL, gp100, P1, P100, SILV, ME20M, ME20-M
Protein Size: 661 - Molecular Weight
- 70 kDa
- Gene ID
- 6490
- NCBI Accession
- NM_006928, NP_008859
- UniProt
- P40967
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