Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) (N-Term) Peptide
SLC12A1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SLC12A1 products
- SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NEKKSRGFFN YQASIFAENF GPRFTKGEGF FSVFAIFFPA ATGILAGANI
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SLC12A1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
- Synonyms
- slc12a1 Peptide, SLC12A1 Peptide, DKFZp469A2020 Peptide, BSC1 Peptide, NKCC2 Peptide, Nkcc2 Peptide, AI788571 Peptide, D630042G03Rik Peptide, mBSC1 Peptide, urehr3 Peptide, si:ch211-220f12.1 Peptide, solute carrier family 12 member 1 Peptide, solute carrier family 12, member 1 Peptide, si:ch211-220f12.1 Peptide, SLC12A1 Peptide, Slc12a1 Peptide
- Background
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This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Alias Symbols: BSC1, NKCC2
Protein Size: 430 - Molecular Weight
- 47 kDa
- Gene ID
- 6557
- NCBI Accession
- NM_000338, NP_000329
- UniProt
- Q8IUN5
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