Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (N-Term) Peptide
TNFRSF1A
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all TNFRSF1A products
- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TNFRSF1A antibody (Catalog #: AVARP00034_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
- Synonyms
- CD120a Peptide, FPF Peptide, MS5 Peptide, TBP1 Peptide, TNF-R Peptide, TNF-R-I Peptide, TNF-R55 Peptide, TNFAR Peptide, TNFR1 Peptide, TNFR1-d2 Peptide, TNFR55 Peptide, TNFR60 Peptide, p55 Peptide, p55-R Peptide, p60 Peptide, TNF-R1 Peptide, TNF-alphaR1 Peptide, TNFRI Peptide, TNFRp55 Peptide, TNFalpha-R1 Peptide, Tnfr-2 Peptide, Tnfr1 Peptide, fpf Peptide, tbp1 Peptide, p55-r Peptide, tnf-r Peptide, tnfar Peptide, tnfr1 Peptide, cd120a Peptide, tnfr55 Peptide, tnfr60 Peptide, xtnfr1 Peptide, wu:fj65b10 Peptide, zgc:85914 Peptide, TNFR I Peptide, TNFRSF1A Peptide, TNFA Peptide, cTNF Peptide, TNF receptor superfamily member 1A Peptide, tumor necrosis factor receptor superfamily, member 1a Peptide, TNF receptor superfamily member 1A S homeolog Peptide, tumor necrosis factor Peptide, TNFRSF1A Peptide, Tnfrsf1a Peptide, tnfrsf1a.S Peptide, tnfrsf1a Peptide, TNF Peptide
- Background
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TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CD120a, FPF, MGC19588, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60
Protein Interaction Partner: ERAP1,GNB2L1,MOAP1,NSMAF,RALBP1,RASSF1,TNF,TNFRSF1A,TRADD,TRADD,TRADD,BAG4,CASP10,CASP7,CHUK,DAPK1,ERAP1,ERN1,FANCD2,GNB2L1,GRB2,HSP90AA1,IKBKB,IKBKG,JAK1,JAK2,LTA,LTB,MADD,MAPK1,MOAP1,MYOC,NSMAF,PIP4K2B,PSMD2,PTK2,PTPN11,PTPN6,RASSF1,RIPK1,RIPK2,RIPK3,STAT1,SUMO1,SYK,TNF,TNFRSF1A,TNFRSF25,TNFSF13,TRADD,TRAF1,TRAF2,TRAP1,TRPC4AP,UBE2I,ARHGDIA,BAG4,BCL10,BID,BIRC2,BIRC3,CASP10,CASP2,CASP7,CASP8,CEP110,CRADD,DAPK1,EZR,FADD,FANCD2,FAS,FASLG,GRB2,HSPA8,IKBKB,IKBKG,JAK1,JAK2,LTA,LTB,MADD,MAPK8,MSN,NOL3,NSMAF,PIP4K2B,PSMD2,RHOA,RIPK1,RIPK2,RIPK3,STAT1,SUMO1,TNF,TNFRSF10B,TNFRSF1A,TNFSF13,TRADD,TRAF1,TRAF2,TRAP1,TRPC4AP,UBE2I
Protein Size: 455 - Molecular Weight
- 48 kDa
- Gene ID
- 7132
- NCBI Accession
- NM_001065, NP_001056
- UniProt
- P19438
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