Thioredoxin Interacting Protein (TXNIP) Peptide
TXNIP
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985779
$160.46
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100 μg
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Quick Overview for Thioredoxin Interacting Protein (TXNIP) Peptide (ABIN985779)
Target
TXNIP
(Thioredoxin Interacting Protein (TXNIP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TXNIP antibody (Catalog #: ARP52193_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TXNIP (Thioredoxin Interacting Protein (TXNIP))
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Background
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TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.
Alias Symbols: EST01027, HHCPA78, THIF, VDUP1
Protein Interaction Partner: KPNA2,TXN,HDAC1,KPNA2,SCEL,SMURF2,TXN,TXNRD1,ZBTB16,ZBTB32,HDAC1,SCEL,TXN,ZBTB16,ZBTB32
Protein Size: 391 -
Molecular Weight
- 44 kDa
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Gene ID
- 10628
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NCBI Accession
- NM_006472, NP_006463
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UniProt
- Q9H3M7
Target
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