Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) Peptide
UBR2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985868
$160.46
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100 μg
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Quick Overview for Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) (C-Term) Peptide (ABIN985868)
Target
UBR2
(Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-UBR2 antibody (Catalog #: ARP43188_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
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Background
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Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron.Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM].
Alias Symbols: C6orf133, DKFZp686C08114, KIAA0349, MGC71112, RP3-392M17.3, bA49A4.1, dJ242G1.1, dJ392M17.3
Protein Interaction Partner: UBE2B,HNRNPA1,UBE2B
Protein Size: 1755 -
Molecular Weight
- 200 kDa
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Gene ID
- 23304
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NCBI Accession
- NM_015255, NP_056070
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UniProt
- Q8IWV8
Target
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