UPF2 Regulator of Nonsense Transcripts 2 (UPF2) (N-Term) Peptide
UPF2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RENT2/UPF2 (UPF2) products
- RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-UPF2 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))
- Synonyms
- HUPF2 Peptide, RENT2 Peptide, smg-3 Peptide, UPF2, regulator of nonsense mediated mRNA decay Peptide, UPF2 regulator of nonsense transcripts homolog (yeast) Peptide, UPF2 Peptide, Upf2 Peptide, upf2 Peptide
- Background
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.
Alias Symbols: DKFZp434D222, HUPF2, KIAA1408, MGC138834, MGC138835, RENT2, smg-3
Protein Interaction Partner: UPF1,DCP1B,DCP2,EIF1,EIF4A1,EIF4G1,EXOSC1,EXOSC10,EXOSC4,EXOSC6,EXOSC8,LSM1,MAP1A,MAP1LC3B,NOB1,PHB2,RPL5,RPS15,RPS25,SKIV2L2,SMG1,UPF1,UPF2,UPF3B,XRN1,XRN2,ZFP36,ZNF408,DCP2,EIF4A1,EXOSC10,EXOSC2,EXOSC4,LSM1,MAP1A,PARN,POLD1,RPS15,RPS25,SMG1,UPF1,UPF2,UP
Protein Size: 1272 - Molecular Weight
- 148 kDa
- Gene ID
- 26019
- NCBI Accession
- NM_015542, NP_056357
- UniProt
- Q9HAU5
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