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Study reveals sCLU as a novel target of DEC1 (BHLHE40) which modulates the sensitivity of the DNA damage response. DEC1 and sCLU are frequently overexpressed in breast cancer.
Gene expression analysis suggests a role of basic helix-loop-helix protein 40 (BHLHE40) in transcriptional activation of heparin-binding epidermal growth factor (HBEGF).
The expression of transcription factor BHLHE40 DEC1/STRA13) is induced in human naive and memory resting B cells by activation through the B-cell receptor (BCR) or Toll-like receptor 9 (TLR9). DEC1/STRA13 is upregulated in human anergic CD21(low) B cells clonally expanded in patients with HCV-associated mixed cryoglobulinemia, which fail to proliferate in response to BCR or TLR9 ligation.
BHLHE40 suppressed CLDN1 transcription by preventing the interaction between SP1 and a specific motif within the promoter region of CLDN1.
The involvement of DEC1 provides new insight into the positive or negative functional roles of p53 in the metformin-induced cytotoxicity in tumor cells.
DEC1 is involved in hypoxia-induced EMT processes via negatively regulating E-cadherin expression in HepG2 cells.
This study was performed to test the hypothesis that the SHP gene is a target gene of DEC1. Cotransfection demonstrated that DEC1 repressed the SHP promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1.
Dec1 is a prognostic factor for the clinical outcome and a predictive factor for the response to TMZ chemotherapy in patients with glioma
decreases of CES and CYP3A4 expression and enzymatic activities induced by Fluoxetine are through decreasing PXR and increasing DEC1 in HepG2 cells
Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.
High BHLHE40 expression is associated with glioblastomas.
STRA13 may be essential for the progression of atopic dermatitis by interacting with hsa-miR-148b and hsamiR- 152.
BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed. The assay revealed high demethylation in activated NK cells and low demethylation in naive NK, T- and B-cells. We conclude the NK cell methylome is plastic with potential for remodeling.
findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo
Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation.
DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line.
The hypoxia-regulated transcription factor DEC1 and its expression in gastric cancer are reported.
IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation.
DEC1 controls the response of p53-dependent cell survival vs. cell death to a stress signal through MIC-1
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Expression of DEC1 is evolutionally conserved in zebrafish.
These results indicate that zDec1 and zDec2 are involved in the circadian clock mechanism in photosensitive zebrafish peripheral cells by suppressing CLOCK/BMAL-induced gene expression.
This study aimed to lay the groundwork to further study of Bhlhe40 function at myogenesis and adipogenesis in bovine and should significantly contribute to cattle breeding and genetics through MAS program
Here we found that the transcription factor Bhlhe40 was required in a cell-intrinsic manner for the self-renewal and maintenance of large peritoneal macrophages (LPMs), but not that of other tissue-resident macrophages.
ranscription factor Bhlhe40 is a molecular switch for determining the fate of inflammatory and antiinflammatory Th1 cells.
Bhlhe40 is required to repress Il10 expression during Mycobacterium tuberculosis infection.
Data show that differentially expressed in chondrocytes 1 protein (DEC1) and circadian locomoter output cycles kaput protein (CLOCK) bound to E-boxes in the beta1 subunit of the Na(+)/K(+)-ATPase (ATP1B1) promoter and suppressed the expression of ATP1B1.
Transcription factor DEC1 can modulate P. gingivalis-induced periodontitis in the oral mucosa.
BHLHE40 is required for insulin induction of SREBP-1c mRNA in rodent liver.
Loss of Bhlhe40 expression is associated with impaired long term potentiation and long term depression at CA1 synapses.
This study demonstrates that downregulation of DEC1 contributes to MPP(+) -induced neurotoxicity by suppressing PI3K/Akt/GSK3beta pathway.
These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-gamma production in iNKT cells.
Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX-IL-1-Bhlhe40 pathway active in experimental autoimmune encephalomyelitis.
Collectively, the data obtained in this study suggest that DEC1 is a novel negative regulator of hepatic FGF21 expression
establishes a crucial role of Bhlhe40 in mediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of Bhlhe40 or p53 may facilitate muscle regeneration after ischemic injuries
There was an inverse relationship between DEC1 expression and AMPK activity. Our results suggest that DEC1 negatively regulates AMPK activity via LKB1
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
Data indicate that bHLH transcription factors Bhlhe40 interacts with PGC-1alpha protein (PGC-1alpha) and represses its transcriptional activity.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2.
studies indicate that DEC1 is an important regulator of Srebp-1c expression and links circadian rhythm to hepatic lipogenesis. Activation of Dec1 can alleviate the nonalcoholic fatty liver phenotype
Study demonstrates that DEC1 is involved in osteogenesis.
Bhlhe40 is required positively regulates the production of GM-CSF and negatively regulates the production of IL-10 in T cells.
we identify DEC1 as a critical transcriptional mediator in the activation of naive CD4(+) T cells that is required for the development of a T cell-mediated autoimmune disease.
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation.
basic helix-loop-helix domain containing, class B, 2
, class B basic helix-loop-helix protein 2
, class E basic helix-loop-helix protein 40
, differentially expressed in chondrocytes 1
, differentially expressed in chondrocytes protein 1
, differentiated embryo chondrocyte expressed gene 1
, enhancer-of-split and hairy-related protein 2
, stimulated by retinoic acid gene 13 protein
, bHLH protein DEC1
, Class B basic helix-loop-helix protein 2
, basic helix-loop-helix domain containing class B2 protein
, basic helix-loop-helix family, member e40
, class E basic helix-loop-helix protein 40-like
, E47 interaction protein 1
, basic helix-loop-helix domain containing, class B2
, cytokine response gene 8
, eip1 (E47 interaction protein 1)
, enhancer-of split and hairy-related protein 2
, stimulated by retinoic acid 14