Browse our anti-PDK4 (PDK4) Antibodies

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

1. In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH (show SAMSN1 Antibodies) via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD (show TSC2 Antibodies).

2. our results suggest that PDK2 (show PDK2 Antibodies)/4 can be a potential target for the development of pharmacotherapy for the treatment of acute inflammatory pain

3. Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cancers

4. PDK4 mediates cisplatin-induced acute kidney injury.

5. Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (show FOXO1 Antibodies) in the heart. FoxO1 (show FOXO1 Antibodies) directly regulates Pdk4 transcription in the heart, thereby controlling PDH (show PDP Antibodies) activity and subsequent glucose oxidation rates.

6. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 (show E2F1 Antibodies) proteins.

7. FXR (show NR1H4 Antibodies) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.

8. Taken together, our results suggest that LPS (show TLR4 Antibodies) induces PDK4 expression and alters glucose metabolism via the JNK (show MAPK8 Antibodies) pathway.

9. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.

10. PDK2 (show PDK2 Antibodies)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

Human Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

1. Results show that PDK4-specific 5'UTR (show UTS2R Antibodies) DNA methylation (show HELLS Antibodies) is positively associated with eicosapentaenoic and arachidonic acid in adult males.

2. it was found that low expression of FAM210B was significantly correlated with decreased survival and enhanced metastasis in vivo and in vitro, and the loss of FAM210B led to an increased mitochondrial respiratory capacity and reduced glycolysis through the downregulation of pyruvate dehydrogenase kinase 4 (PDK4).

3. In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH (show SAMSN1 Antibodies) via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD (show TSC2 Antibodies).

4. Low PDK4 expression is associated with lung tumorigenesis.

5. Increased PDK4 expression is associated with colon cancer.

6. We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation

7. Inhibition of CK2 (show CSNK2A1 Antibodies) increased the expression of metabolic regulators, PDK4 and AMPK (show PRKAA1 Antibodies) along with the key cellular energy sensor CREB (show CREB1 Antibodies).

8. These findings indicate that the TGFbeta (show TGFB1 Antibodies)/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy.

9. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 (show E2F1 Antibodies) proteins.

10. FXR (show NR1H4 Antibodies) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

1. Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (show INS Antibodies) sensitivity by reducing muscle inflammatory responses and improved insulin (show INS Antibodies) inhibition of FOXO1 (show FOXO1 Antibodies)-mediated PDK4 mRNA and protein expression after surgery.

2. Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.