PKM Products
(Pyruvate Kinase M1/2 (PKM))
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This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].
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Featured PKM Categories
PKM Antibodies
High quality antibodies with extensive validation data.
PKM ELISA Kits
Reliable ELISA kits for a wide range of species.
PKM Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKM Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF, IP, FACS
Validations
- (9)
Cat. No.
ABIN7166916
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF, IP, FACS
Validations
- (5)
Cat. No.
ABIN7127769
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7166908
Quantity
100 μg
Datasheet
Datasheet
Recommended PKM ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962948
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969806
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962762
Quantity
96 tests
Datasheet
Datasheet
Recommended PKM Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3093387
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3134427
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2115484
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our PKM products
: "Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling." in: Current cancer drug targets, Vol. 18, Issue 6, pp. 592-599, (2018) (PubMed).: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).
: "PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer." in: Scientific reports, Vol. 7, Issue 1, pp. 2886, (2018) (PubMed).
: "Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317695962, (2017) (PubMed).
: "Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals." in: The Journal of biological chemistry, Vol. 288, Issue 22, pp. 15971-9, (2013) (PubMed).
: "Pharmacologic activation of PKM2 slows lung tumor xenograft growth." in: Molecular cancer therapeutics, Vol. 12, Issue 8, pp. 1453-60, (2013) (PubMed).
: "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2." in: Somatic cell and molecular genetics, Vol. 16, Issue 6, pp. 593-8, (1991) (PubMed).
Synonyms and alternative names related to PKM
pyruvate kinase M1/2 (PKM), pyruvate kinase, muscle (Pkm), Pyruvate kinase (PyK), pyruvate kinase M1/2a (pkma), pyruvate kinase, muscle (pkm), pyruvate kinase, muscle (PKM), pyruvate kinase PKM (LOC710798), pyruvate kinase (PK) (pyk), pyruvate kinase PKM (pk), pyruvate kinase (pk), pyruvate kinase PKM (LOC100534543), pyruvate kinase M1/2 S homeolog (pkm.S), pyruvate kinase M1/2 (Pkm), pyruvate kinase M1/2b (pkmb), AA414905, AL024370, AL024424, cb1029, CG7070, CTHBP, Dmel\\CG7070, fj33f03, MGC53388, OIP3, Pk-2, Pk-3, PK-S, PK3, Pk3, pk3, PKM, PKM2, Pkm2, pkm2, pkm2a, pkm2b, PKM12, PYK, Pyk, TCB, THBP1, wu:fj33f03, zgc:92037Protein level used designations for PKM
- OIP-3
- OPA-interacting protein 3
- PK, muscle type
- cytosolic thyroid hormone-binding protein
- p58
- pyruvate kinase 2/3
- pyruvate kinase PKM
- pyruvate kinase isozymes M1/M2
- pyruvate kinase muscle isozyme
- thyroid hormone-binding protein 1
- thyroid hormone-binding protein, cytosolic
- tumor M2-PK
- pyruvate kinase 3
- CG7070-PA
- CG7070-PB
- PyK-PA
- PyK-PB
- pyruvate kinase
- pyruvate kinase, muscle
- pyruvate kinase M
- ATP:pyruvate 2-o-phosphotransferase
- Pyruvate kinase isozymes M1/M2
- Pyruvate kinase muscle isozyme
- CTHBP
- cytosolic thyroid hormone binding protein/pyruvate kinase type M2
- Pyruvate kinase PKM
- pyruvate kinase, muscle, b
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